SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ako'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		4 / 8 LEU A  27
LEU A 123
GLY A  91
ILE A  77
 None
 0.90A 1n13A-2akoA:
undetectable
1n13F-2akoA:
undetectable		 1n13A-2akoA:
17.92
1n13F-2akoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		3 / 3 ASP A 242
GLU A 251
ARG A 180
 None
 0.61A 1wopA-2akoA:
undetectable		 1wopA-2akoA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		3 / 3 ARG A  23
VAL A  79
GLY A  72
 None
 0.59A 2avvE-2akoA:
undetectable		 2avvE-2akoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		5 / 12 ALA A 227
GLY A 229
ASP A 231
GLY A 247
PHE A 225
 None
 0.97A 2f8lA-2akoA:
2.7		 2f8lA-2akoA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		4 / 6 LEU A  19
VAL A  40
VAL A   8
ILE A 125
 None
 0.98A 2hyyA-2akoA:
undetectable		 2hyyA-2akoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		4 / 6 LEU A  19
VAL A  40
VAL A   8
ILE A 125
 None
 0.94A 2hyyB-2akoA:
undetectable		 2hyyB-2akoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		4 / 8 ILE A  77
LEU A  27
LEU A 123
GLY A  91
 None
 0.91A 2qqdB-2akoA:
undetectable
2qqdC-2akoA:
undetectable		 2qqdB-2akoA:
20.33
2qqdC-2akoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		5 / 12 LEU A 181
THR A 248
GLU A 190
LEU A 211
ILE A 187
 None
 1.36A 2ydoA-2akoA:
undetectable		 2ydoA-2akoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		4 / 8 ILE A  13
LEU A  19
ILE A  77
GLY A  51
 None
 0.88A 4hb6A-2akoA:
undetectable		 4hb6A-2akoA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		6 / 9 SER A  45
GLY A   9
SER A  10
TYR A  80
SER A  14
THR A  44
 None
 1.48A 4lb0A-2akoA:
0.0		 4lb0A-2akoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		5 / 11 ILE A  77
LEU A  42
SER A  10
ILE A  13
LEU A  24
 None
 1.16A 4qleB-2akoA:
undetectable		 4qleB-2akoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		4 / 4 LEU A 123
ARG A   3
ILE A  41
ILE A 114
 None
 1.43A 5dzk2-2akoA:
undetectable
5dzkM-2akoA:
undetectable
5dzkN-2akoA:
undetectable		 5dzk2-2akoA:
1.27
5dzkM-2akoA:
21.91
5dzkN-2akoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		5 / 12 ILE A  77
LEU A  42
SER A  10
ILE A  13
LEU A  24
 None
 1.12A 5hi6A-2akoA:
undetectable		 5hi6A-2akoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		3 / 3 LYS A 212
ASP A 143
ILE A 184
 None
ADP  A 852 ( 4.6A)
None
 0.84A 5kc4E-2akoA:
undetectable		 5kc4E-2akoA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		5 / 12 GLY A   9
SER A  10
ASN A  26
GLU A  22
LEU A  24
 None
 1.26A 5nwuA-2akoA:
undetectable		 5nwuA-2akoA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		5 / 6 LEU A  42
VAL A   5
THR A 150
LEU A 240
GLU A  36
 None
 1.43A 5tudD-2akoA:
undetectable		 5tudD-2akoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2ako GLUTAMATE 5-KINASE
(Campylobacter
jejuni) 		3 / 3 TYR A 168
LEU A 226
ASP A 143
 None
None
ADP  A 852 ( 4.6A)
 0.61A 5zv2B-2akoA:
undetectable		 5zv2B-2akoA:
17.72