SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2akp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 168
GLY A  83
SER A 138
ARG A  78
GLY A  81
 None
 1.49A 1jhqA-2akpA:
undetectable		 1jhqA-2akpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 8 ILE A  66
LEU A 207
ILE A 194
GLU A 192
VAL A 193
 None
 1.24A 1linA-2akpA:
undetectable		 1linA-2akpA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 177
LEU A  75
GLU A  28
LEU A  31
ARG A 189
 None
 1.25A 2bxfA-2akpA:
undetectable		 2bxfA-2akpA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 9 ARG A  65
ASP A  79
ALA A  41
ASP A  40
PRO A 204
 None
 1.25A 3u7sB-2akpA:
undetectable		 3u7sB-2akpA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 THR A 171
LEU A 175
VAL A 130
PHE A  30
PHE A 124
 None
 1.44A 3u9fB-2akpA:
undetectable
3u9fC-2akpA:
undetectable		 3u9fB-2akpA:
20.18
3u9fC-2akpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 SER A 138
SER A 140
LEU A  42
THR A 171
 None
 0.88A 4ikjA-2akpA:
undetectable
4ikjB-2akpA:
undetectable		 4ikjA-2akpA:
20.94
4ikjB-2akpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  42
THR A 171
SER A 138
SER A 140
 None
 0.93A 4ikkA-2akpA:
undetectable
4ikkB-2akpA:
undetectable		 4ikkA-2akpA:
20.94
4ikkB-2akpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 SER A 138
SER A 140
LEU A  42
THR A 171
 None
 0.96A 4iklA-2akpA:
undetectable
4iklB-2akpA:
undetectable		 4iklA-2akpA:
20.94
4iklB-2akpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 9 ARG A  65
ASP A  79
ALA A  41
ASP A  40
PRO A 204
 None
 1.23A 4ll3B-2akpA:
undetectable		 4ll3B-2akpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  35
LEU A 185
VAL A 208
LEU A 207
 None
 0.96A 4r38B-2akpA:
undetectable		 4r38B-2akpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 127
LEU A  75
ILE A 167
GLN A 145
 None
 1.03A 5ljbA-2akpA:
undetectable		 5ljbA-2akpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  89
GLY A  94
PHE A 128
 None
 0.66A 6exiC-2akpA:
undetectable		 6exiC-2akpA:
17.90