SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  11
THR A 184
GLY A  90
LEU A  62
 None
None
AP5  A 301 (-4.3A)
AP5  A 301 ( 4.1A)
 0.85A 1aegA-2akyA:
undetectable		 1aegA-2akyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 122
LEU A 125
VAL A 126
ILE A 129
 None
 0.69A 1s9qA-2akyA:
undetectable		 1s9qA-2akyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
GLY A  61
ALA A 179
THR A 184
ASP A  65
 None
AP5  A 301 (-4.9A)
None
None
None
 1.10A 2c49A-2akyA:
undetectable		 2c49A-2akyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A  35
ALA A 115
TYR A 191
LEU A 112
 AP5  A 301 (-3.0A)
None
None
None
 1.12A 2hzqA-2akyA:
undetectable		 2hzqA-2akyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  90
THR A  35
ILE A  72
LEU A 101
 AP5  A 301 (-4.3A)
AP5  A 301 (-3.0A)
None
None
 0.72A 4ejjD-2akyA:
undetectable		 4ejjD-2akyA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 110
ILE A   5
LEU A  88
ILE A  72
 None
 0.77A 4r38A-2akyA:
undetectable		 4r38A-2akyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 110
ILE A   5
LEU A  88
ILE A  72
 None
 0.81A 4r38D-2akyA:
undetectable		 4r38D-2akyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  33
GLY A  85
ALA A  81
GLU A  75
ARG A  27
 None
 1.27A 4retA-2akyA:
2.4		 4retA-2akyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  33
GLY A  85
ALA A  81
GLU A  75
ARG A  27
 None
 1.27A 4retC-2akyA:
2.4		 4retC-2akyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2aky ADENYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 4 ASN A  23
ILE A 134
TYR A 142
PHE A 146
 None
None
None
AP5  A 301 (-4.7A)
 1.31A 5igvA-2akyA:
undetectable		 5igvA-2akyA:
20.65