SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2akz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 8 ILE A  72
LEU A  76
ILE A   5
VAL A  21
ILE A  68
 None
 1.01A 1linA-2akzA:
undetectable		 1linA-2akzA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 8 GLU A 209
GLY A 395
SER A 369
ASP A 317
ASP A 244
 PO4  A 442 ( 4.5A)
None
F  A 445 ( 4.4A)
MG  A 440 (-3.0A)
MG  A 440 (-2.5A)
 1.49A 1m4iA-2akzA:
undetectable		 1m4iA-2akzA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 11 LEU A 258
PHE A 250
VAL A 288
LEU A 223
LEU A 275
 None
 1.08A 1mx1B-2akzA:
undetectable		 1mx1B-2akzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 4 SER A 114
VAL A  21
PHE A 379
VAL A 343
 None
 1.41A 1o86A-2akzA:
undetectable		 1o86A-2akzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 7 TYR A 406
ILE A 169
PRO A 171
ALA A 180
 None
 0.96A 1oniD-2akzA:
undetectable
1oniE-2akzA:
undetectable		 1oniD-2akzA:
17.78
1oniE-2akzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 ALA A  45
LEU A  48
ILE A  72
ILE A  68
GLY A 112
 None
 1.00A 1qknA-2akzA:
undetectable		 1qknA-2akzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 6 SER A 114
ALA A 352
THR A 322
ALA A  45
 None
 0.92A 1w0gA-2akzA:
undetectable		 1w0gA-2akzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 11 TYR A 256
GLY A 272
LEU A 258
TRP A 303
ALA A 302
 None
 1.41A 2a58A-2akzA:
undetectable
2a58E-2akzA:
undetectable		 2a58A-2akzA:
20.34
2a58E-2akzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 11 TRP A 303
ALA A 302
TYR A 256
GLY A 272
LEU A 258
 None
 1.41A 2a58C-2akzA:
undetectable
2a58D-2akzA:
undetectable		 2a58C-2akzA:
20.34
2a58D-2akzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 11 ILE A 353
LEU A 115
LEU A 129
ILE A 133
ILE A 380
 None
 1.07A 2w9sA-2akzA:
undetectable		 2w9sA-2akzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 11 ILE A 353
LEU A 115
LEU A 129
ILE A 133
ILE A 380
 None
 1.08A 2w9sB-2akzA:
undetectable		 2w9sB-2akzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 8 LEU A 387
THR A 394
VAL A 366
GLY A 390
 None
 0.73A 3dcjB-2akzA:
undetectable		 3dcjB-2akzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 GLY A 242
ILE A 230
ASN A 150
LEU A 170
THR A 190
 None
 1.19A 3eeyE-2akzA:
undetectable		 3eeyE-2akzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 5 GLU A  85
GLN A  86
HIS A 132
GLY A 121
 None
 1.18A 3pp1A-2akzA:
undetectable		 3pp1A-2akzA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 8 GLY A 173
ALA A 174
ASP A 179
GLY A 184
ILE A 169
 None
 1.25A 3so9A-2akzA:
undetectable		 3so9A-2akzA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 VAL A 349
GLN A 408
THR A 378
ILE A 133
PHE A 379
 None
 1.19A 4c49C-2akzA:
undetectable		 4c49C-2akzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 VAL A 349
GLN A 408
THR A 378
ILE A 133
PHE A 379
 None
 1.22A 4c49D-2akzA:
undetectable		 4c49D-2akzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 7 ASP A 317
ASN A 344
GLU A  47
GLU A 374
 MG  A 440 (-3.0A)
None
None
None
 1.22A 4fewB-2akzA:
undetectable		 4fewB-2akzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
 None
 1.24A 4j24C-2akzA:
undetectable		 4j24C-2akzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
 None
 1.16A 4j26B-2akzA:
undetectable		 4j26B-2akzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 8 ARG A 402
ASP A 208
ALA A  38
SER A  39
 None
None
PO4  A 442 (-3.5A)
MG  A 441 (-2.1A)
 1.01A 4lv9A-2akzA:
2.2
4lv9B-2akzA:
undetectable		 4lv9A-2akzA:
23.91
4lv9B-2akzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 VAL A 321
LEU A  94
ALA A  45
LEU A 111
ASN A 344
 None
 1.26A 4qckA-2akzA:
undetectable		 4qckA-2akzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 VAL A 321
LEU A  94
ALA A  45
LEU A 111
ASN A 344
 None
 1.35A 4qdcA-2akzA:
undetectable		 4qdcA-2akzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 ALA A  32
ASP A 377
LEU A  23
HIS A 132
LEU A 129
 None
 1.16A 4xi3A-2akzA:
undetectable		 4xi3A-2akzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 10 GLY A 154
ASN A 150
ILE A 216
LEU A 162
TYR A 199
 None
 1.19A 4xj7A-2akzA:
undetectable
4xj7B-2akzA:
undetectable		 4xj7A-2akzA:
20.58
4xj7B-2akzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 9 SER A  79
VAL A 117
SER A  82
LEU A  81
VAL A  83
 None
 1.34A 4z69A-2akzA:
1.5		 4z69A-2akzA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 9 ASN A 150
HIS A 157
GLY A 154
GLY A 155
ASP A 208
 None
PO4  A 442 (-4.1A)
None
None
None
 1.44A 5f8yA-2akzA:
0.0		 5f8yA-2akzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 9 HIS A 157
GLY A 154
GLY A 155
ASP A 208
ASN A 150
 PO4  A 442 (-4.1A)
None
None
None
None
 1.46A 5f8yA-2akzA:
0.0		 5f8yA-2akzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 9 HIS A 157
GLY A 154
GLY A 155
ASP A 208
ASN A 150
 PO4  A 442 (-4.1A)
None
None
None
None
 1.46A 5f8yB-2akzA:
0.0		 5f8yB-2akzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 9 ASN A 150
HIS A 157
GLY A 154
GLY A 155
ASP A 208
 None
PO4  A 442 (-4.1A)
None
None
None
 1.44A 5f8yB-2akzA:
0.0		 5f8yB-2akzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 ALA A 222
ASP A 244
PHE A 167
GLY A 155
SER A 156
 None
MG  A 440 (-2.5A)
None
None
None
 1.29A 5hfjE-2akzA:
undetectable		 5hfjE-2akzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 7 LEU A 129
ILE A 133
GLY A 386
LEU A 387
ILE A 346
 None
 1.38A 5vkqA-2akzA:
undetectable
5vkqB-2akzA:
undetectable		 5vkqA-2akzA:
13.55
5vkqB-2akzA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		3 / 3 ALA A 174
VAL A 187
TYR A 235
 None
 0.69A 5zmqH-2akzA:
undetectable		 5zmqH-2akzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 9 ASN A 101
ILE A  72
SER A 103
GLY A 112
THR A  71
 None
 1.50A 6awpA-2akzA:
0.0		 6awpA-2akzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		5 / 12 ALA A 308
MET A 243
PHE A 167
ALA A 222
LEU A 278
 None
 1.24A 6aycA-2akzA:
undetectable		 6aycA-2akzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 6 SER A 114
ALA A 352
THR A 322
ALA A  45
 None
 0.99A 6ma6A-2akzA:
undetectable		 6ma6A-2akzA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2akz GAMMA ENOLASE
(Homo
sapiens) 		4 / 7 SER A 114
ALA A 352
THR A 322
ALA A  45
 None
 0.98A 6ma7A-2akzA:
undetectable		 6ma7A-2akzA:
12.39