SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2am2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ALA A  63
PHE A  59
ALA A  29
VAL A  80
ILE A   8
 None
 1.30A 1claA-2am2A:
undetectable		 1claA-2am2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LEU A 302
VAL A 269
LEU A 254
 None
 0.52A 1mz9B-2am2A:
undetectable		 1mz9B-2am2A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 421
ALA A 315
ALA A 314
VAL A 425
LEU A 437
 None
 1.09A 1rbpA-2am2A:
undetectable		 1rbpA-2am2A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 157
LEU A 118
ALA A 119
SER A 123
THR A 144
 None
 0.97A 2aa5B-2am2A:
undetectable		 2aa5B-2am2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A 215
GLY A 107
PRO A 218
ALA A 217
 None
 0.88A 2aohA-2am2A:
undetectable		 2aohA-2am2A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A 321
LEU A 436
SER A 374
LEU A 336
LYS A 333
 None
 1.41A 2ceoB-2am2A:
undetectable		 2ceoB-2am2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 PHE A 256
LEU A 121
LEU A 286
ALA A 258
PHE A 260
 None
 1.27A 2vcvE-2am2A:
undetectable		 2vcvE-2am2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 PHE A 256
LEU A 121
LEU A 286
ALA A 258
PHE A 260
 None
 1.28A 2vcvH-2am2A:
undetectable		 2vcvH-2am2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A 265
LEU A 267
PHE A 256
LEU A 261
 None
 0.91A 2vq5B-2am2A:
undetectable		 2vq5B-2am2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A 433
GLU A 346
GLY A 347
ASP A 381
 None
 1.30A 3w9tD-2am2A:
undetectable		 3w9tD-2am2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ASN A 316
GLY A 317
ALA A 318
ASP A 319
 None
 0.79A 4eyrB-2am2A:
undetectable		 4eyrB-2am2A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 180
ALA A 281
THR A 152
THR A 128
VAL A 100
 None
 1.29A 4qzuA-2am2A:
undetectable		 4qzuA-2am2A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 397
ALA A 355
ILE A 390
ILE A 335
LEU A 336
 None
 1.20A 4r3aA-2am2A:
undetectable		 4r3aA-2am2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A 214
ILE A 167
MET A 159
MET A 209
 None
 1.09A 5ljcA-2am2A:
undetectable		 5ljcA-2am2A:
15.33