SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2am4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		5 / 11 LEU A 230
TYR A 350
TYR A 356
LEU A 237
PRO A 235
 None
 1.11A 1klmA-2am4A:
0.0		 1klmA-2am4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 7 ALA A 416
PHE A 360
ASN A 246
GLU A 309
 None
 1.40A 1t9wA-2am4A:
undetectable		 1t9wA-2am4A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 8 TYR A 442
THR A 263
TYR A 418
LEU A 237
 None
 1.41A 1uw6G-2am4A:
undetectable
1uw6H-2am4A:
undetectable		 1uw6G-2am4A:
19.76
1uw6H-2am4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 8 LEU A 237
TYR A 442
THR A 263
TYR A 418
 None
 1.44A 1uw6P-2am4A:
undetectable
1uw6T-2am4A:
undetectable		 1uw6P-2am4A:
19.76
1uw6T-2am4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		3 / 3 LEU A 260
LEU A 272
PHE A 343
 None
 0.69A 2pgrA-2am4A:
undetectable		 2pgrA-2am4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 7 TRP A 238
LEU A 281
TRP A 293
LYS A 284
 None
 1.36A 3k8mA-2am4A:
undetectable		 3k8mA-2am4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 7 TRP A 238
LEU A 281
TRP A 293
LYS A 284
 None
 1.31A 3k8mB-2am4A:
undetectable		 3k8mB-2am4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A 230
TYR A 350
TYR A 356
LEU A 237
PRO A 235
 None
 0.96A 3mecA-2am4A:
undetectable		 3mecA-2am4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 7 LEU A 124
LEU A 127
PRO A 138
ILE A 139
 None
None
GOL  A 450 ( 4.9A)
GOL  A 450 (-4.4A)
 0.94A 3s56B-2am4A:
undetectable		 3s56B-2am4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		5 / 12 PHE A 316
LEU A 128
TYR A 157
VAL A 161
ALA A 114
 None
None
None
GOL  A 450 (-4.7A)
U2F  A 449 (-4.8A)
 1.44A 4a84A-2am4A:
undetectable		 4a84A-2am4A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 6 PHE A 221
ILE A 108
PHE A 224
PHE A 220
 None
 1.23A 4fgkA-2am4A:
undetectable		 4fgkA-2am4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		3 / 3 ASP A 245
TRP A 290
SER A 241
 None
 0.97A 4lrhB-2am4A:
undetectable		 4lrhB-2am4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		3 / 3 ASP A 245
TRP A 290
SER A 241
 None
 0.98A 4lrhF-2am4A:
undetectable		 4lrhF-2am4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		3 / 3 ARG A 295
PHE A 326
ARG A 415
 None
 1.06A 5y9yA-2am4A:
0.0		 5y9yA-2am4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		3 / 3 TYR A 390
ALA A 402
LEU A 403
 None
 0.67A 6ag0C-2am4A:
undetectable		 6ag0C-2am4A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A 214
THR A 315
GLY A 317
ARG A 117
 None
None
MN  A 448 ( 4.8A)
U2F  A 449 (-2.9A)
 1.13A 6gtqB-2am4A:
0.4
6gtqD-2am4A:
undetectable		 6gtqB-2am4A:
21.60
6gtqD-2am4A:
8.97