SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2amc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL B 125
VAL B  38
TRP B 150
 None
 0.97A 1av2C-2amcB:
undetectable
1av2D-2amcB:
undetectable		 1av2C-2amcB:
2.41
1av2D-2amcB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 10 GLU B 462
ARG B 450
GLU A 262
ALA B 464
GLY B 468
 None
None
MG  A 901 (-2.7A)
None
None
 1.42A 1cmcA-2amcB:
undetectable
1cmcB-2amcB:
undetectable		 1cmcA-2amcB:
7.99
1cmcB-2amcB:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 MET B 230
GLN B 231
PRO B 227
ARG B 240
 None
 1.16A 1dtlA-2amcB:
undetectable		 1dtlA-2amcB:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 4 ALA A 121
GLN B 496
TYR B 492
LEU A 110
 None
 1.40A 1e6wC-2amcA:
undetectable		 1e6wC-2amcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 VAL B  12
LEU B 180
LEU B 177
GLU B  16
GLU B  23
 None
 1.41A 1mmkA-2amcB:
undetectable		 1mmkA-2amcB:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 11 LEU A 219
PHE A 114
GLY A 221
VAL A 261
LEU A 317
 None
None
None
TYR  A 888 (-4.7A)
None
 1.15A 1mx1A-2amcA:
undetectable		 1mx1A-2amcA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 6 SER A 180
THR A 179
ASN A 133
LEU A 174
 TYR  A 888 (-2.7A)
None
None
None
 1.36A 1mxdA-2amcA:
undetectable		 1mxdA-2amcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 LEU B 498
VAL B 501
LEU B 505
 None
 0.40A 1mz9B-2amcB:
undetectable		 1mz9B-2amcB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.17A 1q23C-2amcB:
3.5		 1q23C-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 PHE B 524
PHE B 651
LEU B 670
VAL B 668
ALA B 660
 None
 1.41A 1q23D-2amcB:
3.3
1q23E-2amcB:
3.4		 1q23D-2amcB:
13.12
1q23E-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.14A 1q23E-2amcB:
3.4		 1q23E-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 11 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.17A 1q23F-2amcB:
3.5		 1q23F-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.15A 1q23H-2amcB:
3.3
1q23I-2amcB:
3.4		 1q23H-2amcB:
13.12
1q23I-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 PHE A  96
TYR B 612
LEU B 608
GLY B 591
 None
 0.94A 1rmtC-2amcA:
undetectable		 1rmtC-2amcA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 GLU B 582
GLU A 126
LEU A 161
 None
 0.74A 1v8bA-2amcB:
undetectable		 1v8bA-2amcB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 GLU B 582
GLU A 126
LEU A 161
 None
 0.72A 1v8bB-2amcB:
undetectable		 1v8bB-2amcB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL B 125
VAL B  38
TRP B 150
 None
 0.92A 1w5uC-2amcB:
undetectable
1w5uD-2amcB:
undetectable		 1w5uC-2amcB:
2.41
1w5uD-2amcB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 LEU B 502
PHE B 507
PHE B 617
PHE B 624
LEU B 585
 None
 1.45A 1y7iB-2amcB:
undetectable		 1y7iB-2amcB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 ARG B 486
VAL A 223
GLY A 227
 None
 0.62A 2avvE-2amcB:
undetectable		 2avvE-2amcB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 ARG B  24
LEU B  15
LEU B 170
VAL B   3
 None
 0.95A 2bdmA-2amcB:
undetectable		 2bdmA-2amcB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.08A 2bxeA-2amcA:
undetectable		 2bxeA-2amcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.06A 2bxeB-2amcA:
undetectable		 2bxeB-2amcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 ILE B 466
ARG B 450
LEU B 431
GLU B 462
 None
 0.83A 2cdqA-2amcB:
1.2		 2cdqA-2amcB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 ALA B 179
LEU B   8
LEU B 173
LEU B  28
ARG B  24
 None
 1.29A 2ceoB-2amcB:
undetectable		 2ceoB-2amcB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 GLU A 123
ARG A 201
ARG B 575
GLU A 107
TYR B 492
 None
 1.48A 2htqA-2amcA:
undetectable		 2htqA-2amcA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 VAL B 252
ASN B 250
ALA B 262
GLN B 373
 None
 1.15A 2ij7C-2amcB:
undetectable		 2ij7C-2amcB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL B  38
TRP B 150
VAL B 125
 None
 0.82A 2izqA-2amcB:
undetectable
2izqB-2amcB:
undetectable		 2izqA-2amcB:
2.41
2izqB-2amcB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 5 ALA B 237
TRP B   7
LEU B   8
ALA B 236
 None
 1.17A 2jstA-2amcB:
undetectable
2jstB-2amcB:
undetectable		 2jstA-2amcB:
15.03
2jstB-2amcB:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 5 LEU B 173
LEU B 170
MET B   1
MET B 239
 None
 1.04A 2oaxF-2amcB:
undetectable		 2oaxF-2amcB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.99A 2v2gA-2amcB:
undetectable
2v2gB-2amcB:
undetectable		 2v2gA-2amcB:
13.74
2v2gB-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.99A 2v2gA-2amcB:
undetectable
2v2gB-2amcB:
undetectable		 2v2gA-2amcB:
13.74
2v2gB-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.99A 2v2gC-2amcB:
undetectable
2v2gD-2amcB:
undetectable		 2v2gC-2amcB:
13.74
2v2gD-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 1.00A 2v2gC-2amcB:
undetectable
2v2gD-2amcB:
undetectable		 2v2gC-2amcB:
13.74
2v2gD-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.96A 2v32A-2amcB:
undetectable
2v32B-2amcB:
undetectable		 2v32A-2amcB:
13.74
2v32B-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.98A 2v32A-2amcB:
undetectable
2v32B-2amcB:
undetectable		 2v32A-2amcB:
13.74
2v32B-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.95A 2v32C-2amcB:
undetectable
2v32D-2amcB:
undetectable		 2v32C-2amcB:
13.74
2v32D-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 0.98A 2v41E-2amcB:
undetectable
2v41F-2amcB:
undetectable		 2v41E-2amcB:
13.74
2v41F-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 PRO B 340
VAL B 341
SER B 342
GLU B 208
 None
 1.03A 2v41E-2amcB:
undetectable
2v41F-2amcB:
undetectable		 2v41E-2amcB:
13.74
2v41F-2amcB:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 LEU B 379
ALA B 218
LEU B 333
ALA B 262
 None
 0.83A 2vcvP-2amcB:
undetectable		 2vcvP-2amcB:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 GLY B  86
ALA B  81
LEU B 132
ASP B 138
PHE B  47
 None
 1.11A 2zulA-2amcB:
undetectable		 2zulA-2amcB:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 LEU A 137
PHE A 315
GLY A 284
ILE A 237
PHE A 114
 None
 1.18A 2zzmA-2amcA:
undetectable		 2zzmA-2amcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 LEU A 137
PHE A 315
GLY A 284
ILE A 237
PHE A 114
 None
 1.14A 2zznA-2amcA:
undetectable		 2zznA-2amcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 MET B   1
LEU B 158
ASN B 163
VAL B  12
LEU B 177
 None
 1.22A 3a51B-2amcB:
undetectable		 3a51B-2amcB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 PRO B 666
LEU B 560
THR B 512
VAL B 510
LEU B 570
 None
 1.38A 3a51B-2amcB:
undetectable		 3a51B-2amcB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 GLY B  86
ALA B  81
LEU B 132
ASP B 138
PHE B  47
 None
 1.12A 3dmhA-2amcB:
undetectable		 3dmhA-2amcB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 SER A 180
THR A 179
GLY A 282
GLY A 316
VAL A 261
 TYR  A 888 (-2.7A)
None
TYR  A 888 ( 4.0A)
TYR  A 888 (-3.6A)
TYR  A 888 (-4.7A)
 0.99A 3fzgA-2amcA:
undetectable		 3fzgA-2amcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 TYR A 307
PHE A 291
VAL A 294
THR A 179
 None
 0.84A 3gssA-2amcA:
undetectable		 3gssA-2amcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 TYR A 307
PHE A 291
VAL A 294
THR A 179
 None
 0.83A 3gssB-2amcA:
undetectable		 3gssB-2amcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 GLY B 271
PRO B 199
LEU B 265
 None
 0.59A 3hcpB-2amcB:
undetectable		 3hcpB-2amcB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 ARG B 486
GLU B 489
TYR A 186
 None
 0.93A 3k37B-2amcB:
undetectable		 3k37B-2amcB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 GLU A 123
ARG A 201
ARG B 575
GLU A 107
TYR B 492
 None
 1.50A 3k39F-2amcA:
undetectable		 3k39F-2amcA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 4 ARG B   2
ASP B 176
GLY B  29
THR B  32
 None
 1.16A 3k4vB-2amcB:
undetectable		 3k4vB-2amcB:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 6 LEU B  25
ILE B 466
ALA B 174
LEU B 171
 None
 0.79A 3kk6B-2amcB:
undetectable		 3kk6B-2amcB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL B 125
VAL B  38
TRP B 150
 None
 0.72A 3l8lA-2amcB:
undetectable
3l8lB-2amcB:
undetectable		 3l8lA-2amcB:
2.41
3l8lB-2amcB:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL B 125
VAL B  38
TRP B 150
 None
 0.84A 3l8lC-2amcB:
undetectable
3l8lD-2amcB:
undetectable		 3l8lC-2amcB:
2.41
3l8lD-2amcB:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 ARG B 362
ASP B  33
GLN A 254
 None
 0.70A 3lcvB-2amcB:
undetectable		 3lcvB-2amcB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 9 ARG B 499
ILE A 103
LEU B 498
GLU B 500
GLY A  98
 None
 1.30A 3nxuB-2amcB:
undetectable		 3nxuB-2amcB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 5 SER A 180
GLY A 281
GLU B  31
GLU A 279
 TYR  A 888 (-2.7A)
None
None
None
 1.18A 3raeB-2amcA:
1.6
3raeD-2amcA:
undetectable		 3raeB-2amcA:
20.59
3raeD-2amcA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 6 LEU B 379
SER B 378
ALA B 190
LEU B 383
 None
 1.10A 3rd0A-2amcB:
undetectable		 3rd0A-2amcB:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 11 PHE B 338
PHE B 360
PHE B 263
ILE B 300
GLY B 312
 TYR  B 999 (-4.5A)
TYR  B 999 ( 4.8A)
None
None
None
 1.11A 3t3rA-2amcB:
undetectable		 3t3rA-2amcB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ARG A 204
GLN A 218
PHE A 258
GLY A 281
GLY A 316
 TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.0A)
None
TYR  A 888 (-3.6A)
 0.95A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		10 / 12 SER A 180
ARG A 204
GLN A 218
GLU A 220
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 TYR  A 888 (-2.7A)
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.5A)
TYR  A 888 (-3.0A)
TYR  A 888 (-4.5A)
TYR  A 888 ( 4.0A)
None
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.60A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		10 / 12 SER A 180
GLN A 183
ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 TYR  A 888 (-2.7A)
None
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.0A)
TYR  A 888 (-4.5A)
TYR  A 888 ( 4.0A)
None
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.54A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 TRP A 149
ARG A 204
VAL A 261
ALA A 314
GLY A 282
 TYR  A 888 (-4.1A)
TYR  A 888 (-3.9A)
TYR  A 888 (-4.7A)
TYR  A 888 (-3.4A)
TYR  A 888 ( 4.0A)
 1.45A 3tehA-2amcA:
42.2		 3tehA-2amcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		9 / 9 TRP A 149
HIS A 178
SER A 180
ARG A 204
GLN A 218
GLU A 220
VAL A 261
ALA A 314
GLY A 316
 TYR  A 888 (-4.1A)
TYR  A 888 (-3.7A)
TYR  A 888 (-2.7A)
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.5A)
TYR  A 888 (-4.7A)
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.48A 3tehA-2amcA:
42.2		 3tehA-2amcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		7 / 7 PRO B 259
HIS B 261
LEU B 286
GLY B 315
GLU B 334
ALA B 356
PHE B 360
 None
TYR  B 999 (-3.6A)
TYR  B 999 (-4.1A)
TYR  B 999 (-3.2A)
TYR  B 999 (-3.5A)
TYR  B 999 (-3.1A)
TYR  B 999 ( 4.8A)
 0.39A 3tehB-2amcB:
60.1		 3tehB-2amcB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.10A 3u9fI-2amcB:
3.2		 3u9fI-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.14A 3u9fJ-2amcB:
1.1
3u9fK-2amcB:
undetectable		 3u9fJ-2amcB:
13.12
3u9fK-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.15A 3u9fR-2amcB:
3.2		 3u9fR-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 TYR A 119
MET A 106
LEU A 244
 None
 0.99A 3vw1D-2amcA:
undetectable		 3vw1D-2amcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 ALA B 301
LEU B 298
SER B 322
PHE B 213
GLY B 209
 None
 1.02A 4dm8B-2amcB:
undetectable		 4dm8B-2amcB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 5 LEU B  25
LEU B 173
MET B   1
TRP B   7
 None
 1.45A 4do3A-2amcB:
undetectable		 4do3A-2amcB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 ASP B 696
VAL B 768
PHE B 749
LEU B 722
 None
 1.06A 4f8hA-2amcB:
undetectable
4f8hB-2amcB:
undetectable		 4f8hA-2amcB:
17.62
4f8hB-2amcB:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 4 LEU A 110
LEU A 105
GLN A 218
GLU A 123
 None
None
TYR  A 888 (-3.3A)
None
 1.15A 4i41A-2amcA:
undetectable		 4i41A-2amcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 THR B 354
ASN B 250
GLN B 231
LEU B 234
 None
 0.85A 4ib4A-2amcB:
undetectable		 4ib4A-2amcB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 ALA B  90
PRO B  92
LEU B  96
LEU B 118
 None
 0.92A 4jjkA-2amcB:
undetectable		 4jjkA-2amcB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 PHE B 213
GLY B 271
LEU B 202
ALA B 273
ILE B 300
 None
 1.12A 4krhB-2amcB:
undetectable		 4krhB-2amcB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 HIS A 190
VAL A 286
LEU A 222
 None
 0.49A 4m2vA-2amcA:
undetectable		 4m2vA-2amcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 8 GLU B 137
VAL B  65
LEU B  66
PHE B  47
GLY B 143
 None
 1.46A 4r3aA-2amcB:
undetectable		 4r3aA-2amcB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLY A 281
PHE A 315
LEU A 233
ALA A 236
ALA A 241
 None
 1.36A 4wnuD-2amcA:
undetectable		 4wnuD-2amcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 ASP B  33
ARG B 359
ARG B 353
 None
 0.78A 4x5iA-2amcB:
undetectable		 4x5iA-2amcB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 ASP B 157
ARG B 359
ARG B 353
 None
 0.97A 4x5iA-2amcB:
undetectable		 4x5iA-2amcB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU B 122
VAL B 125
LEU B  96
SER B 119
LEU B 133
 None
 1.28A 4yb6A-2amcB:
5.8
4yb6E-2amcB:
5.8		 4yb6A-2amcB:
19.48
4yb6E-2amcB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU B 122
VAL B 125
LEU B  96
SER B 119
LEU B 133
 None
 1.28A 4yb6B-2amcB:
5.8
4yb6C-2amcB:
5.7		 4yb6B-2amcB:
19.48
4yb6C-2amcB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU B 122
VAL B 125
LEU B  96
SER B 119
LEU B 133
 None
 1.28A 4yb6C-2amcB:
5.7
4yb6F-2amcB:
5.8		 4yb6C-2amcB:
19.48
4yb6F-2amcB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 LEU B  96
SER B 119
LEU B 133
GLU B 122
VAL B 125
 None
 1.27A 4yb6A-2amcB:
5.8
4yb6D-2amcB:
5.8		 4yb6A-2amcB:
19.48
4yb6D-2amcB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 LEU B  96
SER B 119
LEU B 133
GLU B 122
VAL B 125
 None
 1.27A 4yb6D-2amcB:
5.8
4yb6E-2amcB:
5.8		 4yb6D-2amcB:
19.48
4yb6E-2amcB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 10 LEU B  96
SER B 119
LEU B 133
GLU B 122
VAL B 125
 None
 1.28A 4yb6B-2amcB:
5.8
4yb6F-2amcB:
5.8		 4yb6B-2amcB:
19.48
4yb6F-2amcB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 6 TYR B 612
GLY B 595
SER A  94
LEU A  95
 None
 1.05A 5bphA-2amcB:
undetectable		 5bphA-2amcB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 7 TYR B 612
GLY B 595
SER A  94
LEU A  95
 None
 1.06A 5bphB-2amcB:
undetectable		 5bphB-2amcB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 4 TYR B 612
GLY B 595
SER A  94
LEU A  95
 None
 1.03A 5bphC-2amcB:
undetectable		 5bphC-2amcB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 6 TYR B 612
GLY B 595
SER A  94
LEU A  95
 None
 1.02A 5bphD-2amcB:
undetectable		 5bphD-2amcB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 GLY B 778
GLY B 781
LEU B 697
ALA B 774
LEU B 713
 None
 0.98A 5c0oF-2amcB:
undetectable		 5c0oF-2amcB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 ASP B 157
ARG B 359
ARG B 353
 None
 0.98A 5eajB-2amcB:
undetectable		 5eajB-2amcB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 LEU A 161
LEU A 301
PHE A 131
GLU A 128
ALA A 136
 None
 1.28A 5ieoA-2amcA:
undetectable		 5ieoA-2amcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 8 ALA B 717
LEU B 747
LEU B 725
LEU B 772
LEU B 697
 None
 1.29A 5jqbA-2amcB:
undetectable
5jqbB-2amcB:
undetectable		 5jqbA-2amcB:
18.06
5jqbB-2amcB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 12 ARG B 465
GLN B 424
GLY B 416
THR B 417
GLN B 467
 None
 1.23A 5oj0A-2amcB:
2.8		 5oj0A-2amcB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 VAL B 268
GLY B 216
LEU B 393
THR B 214
 None
 1.10A 5syjA-2amcB:
undetectable		 5syjA-2amcB:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 LEU A 244
ALA A 241
LEU A 322
 None
 0.50A 5uunB-2amcA:
undetectable		 5uunB-2amcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		3 / 3 LEU B 313
ALA B 314
LEU B 293
 None
 0.55A 5uunB-2amcB:
undetectable		 5uunB-2amcB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 7 ARG B 450
ARG B 164
THR B 161
PRO B 162
 None
 1.50A 6a4iB-2amcB:
undetectable		 6a4iB-2amcB:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 VAL A 310
ALA A 306
ASP A 295
PHE A 291
VAL A 224
 None
 1.19A 6aogA-2amcA:
undetectable		 6aogA-2amcA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 VAL A 310
ALA A 306
ASP A 295
PHE A 291
VAL A 224
 None
 1.16A 6aogB-2amcA:
undetectable		 6aogB-2amcA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU A 206
HIS A 212
PHE A 216
GLY A 318
ILE A 332
 None
 0.76A 6bniA-2amcA:
5.2		 6bniA-2amcA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU A 206
HIS A 212
PHE A 216
GLY A 318
ILE A 332
 None
 0.83A 6bniB-2amcA:
13.7		 6bniB-2amcA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 LEU B 544
ASN A 133
LEU A 161
 None
 0.68A 6exiA-2amcB:
undetectable		 6exiA-2amcB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 6 VAL B 223
ASN B 243
ILE B 242
GLU B 323
 None
 1.01A 6h7uA-2amcB:
undetectable		 6h7uA-2amcB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 VAL B 223
ASN B 243
ILE B 242
GLU B 323
 None
 1.06A 6hzpA-2amcB:
undetectable		 6hzpA-2amcB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 ASP B 166
HIS B 449
ASP B 458
GLU B 461
 None
None
MG  A 901 ( 4.9A)
MG  A 901 (-3.1A)
 1.26A 6mn4B-2amcB:
undetectable		 6mn4B-2amcB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 8 ARG B 276
HIS B 294
ASP B 206
GLU B 208
 None
 1.15A 6mn4C-2amcB:
undetectable		 6mn4C-2amcB:
17.09