SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2amg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		6 / 12 TYR A  78
ARG A 191
ASP A 193
GLU A 219
HIS A 293
ASP A 294
 None
 0.84A 1dedB-2amgA:
27.2		 1dedB-2amgA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		7 / 12 TRP A  25
HIS A 117
ARG A 191
ASP A 193
GLU A 219
TRP A 221
ASP A 294
 None
 0.85A 1mxdA-2amgA:
36.0		 1mxdA-2amgA:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		8 / 12 TRP A  25
TYR A  78
HIS A 117
ARG A 191
ASP A 193
GLU A 219
TRP A 221
HIS A 293
 None
 0.65A 1mxdA-2amgA:
36.0		 1mxdA-2amgA:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		7 / 12 TRP A  25
TYR A  78
HIS A 117
PHE A 156
ARG A 191
ASP A 193
HIS A 293
 None
 0.77A 1mxdA-2amgA:
36.0		 1mxdA-2amgA:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 ASP A  62
HIS A 117
ASP A 193
 None
 0.82A 1nw5A-2amgA:
undetectable		 1nw5A-2amgA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 VAL A  58
HIS A 307
GLU A 219
ASP A 112
 None
 1.27A 1s3zA-2amgA:
1.1
1s3zB-2amgA:
1.2		 1s3zA-2amgA:
16.99
1s3zB-2amgA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		5 / 12 GLY A  73
GLY A  74
GLU A  76
ASP A 294
SER A  67
 None
 1.19A 1xdsA-2amgA:
undetectable		 1xdsA-2amgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 4 LEU A 220
SER A 225
ASP A 154
ASP A 162
 None
None
None
CA  A 451 (-3.3A)
 1.49A 2br4B-2amgA:
undetectable		 2br4B-2amgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 4 SER A 210
TRP A 206
ASP A  82
ILE A 127
 None
 1.49A 2oxtD-2amgA:
0.0		 2oxtD-2amgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 THR A 328
PRO A 329
VAL A 330
ALA A  53
 None
 1.07A 2v41G-2amgA:
undetectable
2v41H-2amgA:
undetectable		 2v41G-2amgA:
19.76
2v41H-2amgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		5 / 12 SER A  52
ILE A  46
LEU A 102
GLY A 103
GLY A 106
 None
 1.10A 3axzA-2amgA:
undetectable		 3axzA-2amgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 TYR A 297
ASP A 291
ASP A 294
 None
 0.92A 3ou7B-2amgA:
undetectable		 3ou7B-2amgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 LEU A  95
ALA A  99
TYR A 185
TYR A 111
 None
 1.09A 3rodA-2amgA:
undetectable		 3rodA-2amgA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 4 VAL A 195
PHE A 192
PHE A 215
VAL A 287
 None
 1.50A 3rv5C-2amgA:
undetectable
3rv5D-2amgA:
undetectable		 3rv5C-2amgA:
11.46
3rv5D-2amgA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 7 PRO A  32
ARG A  29
GLY A 300
PRO A 299
 None
 1.38A 3ucbB-2amgA:
undetectable		 3ucbB-2amgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 ILE A 127
LEU A 129
GLY A 172
TRP A 206
 None
 0.69A 3w1wA-2amgA:
undetectable		 3w1wA-2amgA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 6 ILE A 315
TRP A  55
ILE A  54
TRP A 333
 None
 1.50A 3weoA-2amgA:
undetectable		 3weoA-2amgA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 7 ASN A 128
GLU A 126
ILE A 127
ASN A 119
 None
 1.12A 4d39B-2amgA:
undetectable		 4d39B-2amgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 7 PRO A 326
VAL A 376
ALA A 374
PHE A 365
 None
 1.14A 4lb2A-2amgA:
undetectable		 4lb2A-2amgA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 5 PRO A 329
GLY A 327
ASP A 112
ASP A 255
 None
 1.12A 4n48B-2amgA:
undetectable		 4n48B-2amgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 ASN A 393
PRO A 394
PHE A 402
SER A 403
 None
 1.33A 5amiB-2amgA:
undetectable		 5amiB-2amgA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 LEU A 274
LEU A 258
TRP A 270
 None
 0.90A 5nwuA-2amgA:
undetectable		 5nwuA-2amgA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		5 / 11 ASP A  49
ILE A  46
ILE A 345
GLY A 342
VAL A 331
 None
 0.81A 5twjD-2amgA:
undetectable		 5twjD-2amgA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		6 / 12 TRP A  25
TYR A  78
HIS A 117
GLU A 226
ASP A 193
HIS A 293
 None
 0.63A 6ag0A-2amgA:
32.8		 6ag0A-2amgA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		4 / 6 PHE A 289
ILE A 322
ASN A 275
ASP A 255
 None
 1.22A 6dhbA-2amgA:
undetectable		 6dhbA-2amgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 LEU A 274
GLY A 327
PHE A 215
 None
 0.51A 6exiC-2amgA:
undetectable		 6exiC-2amgA:
11.03