SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2amh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.76A 1c9sI-2amhA:
undetectable
1c9sJ-2amhA:
undetectable		 1c9sI-2amhA:
19.19
1c9sJ-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.75A 1c9sU-2amhA:
undetectable
1c9sV-2amhA:
undetectable		 1c9sU-2amhA:
19.19
1c9sV-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.74A 1gtnA-2amhA:
undetectable
1gtnK-2amhA:
undetectable		 1gtnA-2amhA:
19.19
1gtnK-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.75A 1gtnA-2amhA:
undetectable
1gtnB-2amhA:
undetectable		 1gtnA-2amhA:
19.19
1gtnB-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.80A 1gtnC-2amhA:
undetectable
1gtnD-2amhA:
undetectable		 1gtnC-2amhA:
19.19
1gtnD-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.80A 1gtnD-2amhA:
undetectable
1gtnE-2amhA:
undetectable		 1gtnD-2amhA:
19.19
1gtnE-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.76A 1gtnE-2amhA:
undetectable
1gtnF-2amhA:
undetectable		 1gtnE-2amhA:
19.19
1gtnF-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.73A 1gtnF-2amhA:
undetectable
1gtnG-2amhA:
undetectable		 1gtnF-2amhA:
19.19
1gtnG-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.77A 1gtnJ-2amhA:
undetectable
1gtnK-2amhA:
undetectable		 1gtnJ-2amhA:
19.19
1gtnK-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.77A 1gtnP-2amhA:
undetectable
1gtnQ-2amhA:
undetectable		 1gtnP-2amhA:
19.19
1gtnQ-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.79A 1utdB-2amhA:
undetectable
1utdC-2amhA:
undetectable		 1utdB-2amhA:
19.19
1utdC-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.78A 1utdF-2amhA:
undetectable
1utdG-2amhA:
undetectable		 1utdF-2amhA:
19.19
1utdG-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.76A 1utdI-2amhA:
undetectable
1utdJ-2amhA:
undetectable		 1utdI-2amhA:
19.19
1utdJ-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.77A 1utdJ-2amhA:
undetectable
1utdK-2amhA:
undetectable		 1utdJ-2amhA:
19.19
1utdK-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 5 SER A 167
LEU A 159
GLY A 162
CYH A 108
 None
 1.02A 3aiaA-2amhA:
undetectable
3aiaB-2amhA:
undetectable		 3aiaA-2amhA:
23.73
3aiaB-2amhA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  69
MET A  65
THR A  87
ALA A  85
ILE A  13
 None
 1.16A 4x1iD-2amhA:
undetectable		 4x1iD-2amhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 ILE A   9
PRO A  82
VAL A  68
LEU A  69
LEU A 207
 None
 1.49A 5iepA-2amhA:
undetectable		 5iepA-2amhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 126
THR A  87
THR A  16
ILE A  60
 None
None
SO4  A 401 (-3.8A)
MN  A2001 ( 4.9A)
 1.00A 5jhdE-2amhA:
undetectable
5jhdG-2amhA:
undetectable		 5jhdE-2amhA:
23.69
5jhdG-2amhA:
20.39