SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 4 VAL A 238
PHE A 230
SER A 242
VAL A 240
 None
 1.38A 1e7cA-2amlA:
1.3		 1e7cA-2amlA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 TRP A  41
LEU A 160
GLY A 162
LEU A  30
 None
 0.89A 1gtiA-2amlA:
undetectable		 1gtiA-2amlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 TRP A  41
LEU A 160
GLY A 162
LEU A  30
 None
 0.93A 1gtiB-2amlA:
undetectable		 1gtiB-2amlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 TRP A  41
LEU A 160
GLY A 162
LEU A  30
 None
 0.91A 1gtiD-2amlA:
1.0		 1gtiD-2amlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 TRP A  41
LEU A 160
GLY A 162
LEU A  30
 None
 0.96A 1gtiE-2amlA:
undetectable		 1gtiE-2amlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		3 / 3 THR A 152
LEU A 156
LEU A 163
 None
 0.39A 1mz9C-2amlA:
undetectable		 1mz9C-2amlA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		3 / 3 THR A 101
LEU A 105
VAL A 108
 None
 0.64A 1mz9E-2amlA:
undetectable		 1mz9E-2amlA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 TYR A 360
THR A  99
GLU A 126
SER A  95
 None
None
None
PO4  A 362 (-2.9A)
 1.23A 1tv8A-2amlA:
undetectable		 1tv8A-2amlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 9 LEU A 119
LEU A 135
ILE A 133
LEU A  88
ILE A  90
 None
 1.23A 2f7aB-2amlA:
1.2		 2f7aB-2amlA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 THR A 154
LEU A  30
ASP A 132
ALA A  45
VAL A  89
 None
 1.36A 2g72A-2amlA:
undetectable		 2g72A-2amlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 6 SER A  32
VAL A  34
ASP A 132
PRO A 115
 None
 1.25A 2hdnJ-2amlA:
undetectable
2hdnK-2amlA:
undetectable
2hdnL-2amlA:
2.8		 2hdnJ-2amlA:
23.10
2hdnK-2amlA:
6.43
2hdnL-2amlA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 8 GLY A 138
SER A 139
SER A  49
ASP A 136
THR A 134
 None
None
PO4  A 362 (-2.5A)
None
None
 1.29A 3pwwA-2amlA:
undetectable		 3pwwA-2amlA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 6 ILE A 218
THR A 216
VAL A 278
ASP A 301
 None
 1.17A 4iaqA-2amlA:
undetectable		 4iaqA-2amlA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 5 TYR A 220
THR A 198
LEU A 327
THR A 216
 None
 1.36A 4mbsB-2amlA:
undetectable		 4mbsB-2amlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 8 GLU A  12
ILE A 321
GLU A 229
LEU A 327
 None
 0.95A 4mj8A-2amlA:
undetectable		 4mj8A-2amlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLU A  40
ARG A  67
ILE A  68
GLN A  54
ILE A  43
 None
 1.29A 4uroA-2amlA:
undetectable		 4uroA-2amlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 ASP A 301
THR A 304
TYR A 292
THR A 291
 None
 1.35A 5b6iA-2amlA:
2.0		 5b6iA-2amlA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 6 ASP A 301
THR A 304
TYR A 292
THR A 291
 None
 1.36A 5b6iB-2amlA:
2.1		 5b6iB-2amlA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2aml SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 ILE A 307
LEU A 267
THR A 274
ARG A 303
 None
 1.04A 5vc0A-2amlA:
0.4		 5vc0A-2amlA:
19.88