SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2amy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 VAL A 231
TYR A 205
TYR A 229
GLY A 208
 None
 1.02A 1lweA-2amyA:
2.8		 1lweA-2amyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 8 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.85A 1rtsA-2amyA:
undetectable		 1rtsA-2amyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.86A 1rtsB-2amyA:
undetectable		 1rtsB-2amyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 5 TYR A 102
SER A 105
CYH A 103
TYR A 106
 GLY  A 402 (-3.2A)
GLY  A 402 (-4.3A)
None
EDO  A 300 (-4.0A)
 1.37A 2kqeA-2amyA:
0.0		 2kqeA-2amyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.81A 2tsrA-2amyA:
undetectable		 2tsrA-2amyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 8 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.85A 2tsrB-2amyA:
undetectable		 2tsrB-2amyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		5 / 12 VAL A 231
TYR A 205
TYR A 229
GLY A 208
PRO A 234
 None
 1.22A 3mecA-2amyA:
2.7		 3mecA-2amyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		5 / 12 GLY A  15
GLN A  55
VAL A  52
ASP A 188
PHE A 206
 None
 1.24A 3qowA-2amyA:
undetectable		 3qowA-2amyA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		5 / 12 GLY A  42
VAL A 231
ASP A  12
MET A  28
LEU A  32
 None
 1.41A 4a83A-2amyA:
0.1		 4a83A-2amyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.84A 4iqqA-2amyA:
undetectable		 4iqqA-2amyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.76A 4iqqC-2amyA:
undetectable		 4iqqC-2amyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 8 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.81A 4iqqD-2amyA:
undetectable		 4iqqD-2amyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 8 ILE A 240
PHE A  11
TYR A 205
LEU A  35
 None
 0.95A 4qopC-2amyA:
undetectable		 4qopC-2amyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 8 THR A 237
ILE A  41
VAL A  52
LEU A  56
 None
 0.96A 4r38B-2amyA:
undetectable		 4r38B-2amyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.86A 5h3aA-2amyA:
undetectable		 5h3aA-2amyA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.83A 5nooA-2amyA:
undetectable		 5nooA-2amyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 8 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.83A 5nooD-2amyA:
undetectable		 5nooD-2amyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens) 		4 / 7 GLY A 117
THR A 118
PHE A 119
SER A 179
 None
 0.69A 6jnhA-2amyA:
3.0		 6jnhA-2amyA:
22.00