SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2an1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		3 / 3 LYS A 284
ASP A 105
ASN A  97
 LYS  A 284 ( 0.0A)
ASP  A 105 ( 0.6A)
ASN  A  97 ( 0.6A)
 1.16A 2bm9A-2an1A:
2.8		 2bm9A-2an1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 12 ALA A  67
VAL A 116
ASN A  89
GLY A   9
ILE A   8
 ALA  A  67 ( 0.0A)
VAL  A 116 ( 0.6A)
ASN  A  89 ( 0.6A)
GLY  A   9 ( 0.0A)
ILE  A   8 ( 0.7A)
 1.47A 3a65A-2an1A:
undetectable		 3a65A-2an1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		4 / 8 PHE A 170
SER A 173
LEU A 231
ASP A 257
 PHE  A 170 ( 1.3A)
SER  A 173 ( 0.0A)
LEU  A 231 ( 0.5A)
ASP  A 257 ( 0.6A)
 1.06A 3m0wE-2an1A:
undetectable
3m0wF-2an1A:
undetectable
3m0wG-2an1A:
undetectable
3m0wH-2an1A:
undetectable		 3m0wE-2an1A:
13.79
3m0wF-2an1A:
13.79
3m0wG-2an1A:
13.79
3m0wH-2an1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 11 ILE A 146
ASN A 268
ILE A  88
LEU A 267
THR A 144
 ILE  A 146 ( 0.7A)
ASN  A 268 ( 0.6A)
ILE  A  88 ( 0.7A)
LEU  A 267 ( 0.6A)
THR  A 144 ( 0.8A)
 1.17A 3qg2B-2an1A:
undetectable		 3qg2B-2an1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 12 ILE A 206
ILE A 229
VAL A 164
LEU A 231
ILE A 242
 ILE  A 206 ( 0.7A)
ILE  A 229 ( 0.7A)
VAL  A 164 ( 0.6A)
LEU  A 231 ( 0.5A)
ILE  A 242 ( 0.7A)
 1.08A 3w67D-2an1A:
undetectable		 3w67D-2an1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 12 ILE A 223
ALA A 205
LEU A 129
SER A 191
ILE A 180
 ILE  A 223 ( 0.7A)
ALA  A 205 ( 0.0A)
LEU  A 129 ( 0.6A)
SER  A 191 ( 0.0A)
ILE  A 180 ( 0.7A)
 1.30A 4gh8B-2an1A:
undetectable		 4gh8B-2an1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		4 / 8 THR A 183
LEU A  77
VAL A  90
LEU A 269
 THR  A 183 ( 0.8A)
LEU  A  77 ( 0.6A)
VAL  A  90 ( 0.6A)
LEU  A 269 ( 0.6A)
 0.94A 4r38B-2an1A:
undetectable		 4r38B-2an1A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		4 / 6 ASP A 264
THR A 183
PRO A 184
THR A 185
 ASP  A 264 ( 0.6A)
THR  A 183 ( 0.8A)
PRO  A 184 ( 1.1A)
THR  A 185 ( 0.8A)
 1.14A 4yoaA-2an1A:
undetectable		 4yoaA-2an1A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 12 GLY A  55
ALA A  67
LEU A  66
ALA A  58
GLY A  61
 GLY  A  55 ( 0.0A)
ALA  A  67 ( 0.0A)
LEU  A  66 ( 0.6A)
ALA  A  58 ( 0.0A)
GLY  A  61 ( 0.0A)
 1.26A 5jglB-2an1A:
undetectable		 5jglB-2an1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 8 VAL A 164
ILE A 260
LEU A 231
ILE A 181
ILE A 206
 VAL  A 164 ( 0.6A)
ILE  A 260 ( 0.5A)
LEU  A 231 ( 0.5A)
ILE  A 181 ( 0.6A)
ILE  A 206 ( 0.7A)
 1.23A 5numA-2an1A:
undetectable		 5numA-2an1A:
17.09