SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2an2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 11 VAL A 221
GLY A 222
TYR A  41
TYR A  15
GLU A  17
 None
 1.27A 1iolA-2an2A:
undetectable		 1iolA-2an2A:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 6 GLY A  64
TRP A 234
VAL A 296
ALA A 301
 HEM  A 901 ( 3.9A)
HEM  A 901 ( 3.6A)
None
None
 0.25A 1p6kA-2an2A:
48.8		 1p6kA-2an2A:
40.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.91A 1vptA-2an2A:
undetectable		 1vptA-2an2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 TRP A  68
ARG A  65
PHE A 308
 None
 1.05A 1zeaH-2an2A:
undetectable
1zeaL-2an2A:
undetectable		 1zeaH-2an2A:
19.50
1zeaL-2an2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 5 PRO A 329
GLY A 237
ASN A 281
GLY A 241
 None
 1.14A 1zlqA-2an2A:
undetectable		 1zlqA-2an2A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 11 TYR A 129
PHE A 163
ILE A 240
TYR A 288
ILE A 189
 None
 1.13A 2dg3A-2an2A:
undetectable		 2dg3A-2an2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 7 ALA A  52
TYR A 351
ILE A 108
HIS A  92
 None
HEM  A 901 (-4.4A)
None
None
 1.10A 2zm7A-2an2A:
undetectable		 2zm7A-2an2A:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 GLY A  64
TRP A 234
VAL A 296
 HEM  A 901 ( 3.9A)
HEM  A 901 ( 3.6A)
None
 0.27A 3n62B-2an2A:
48.8		 3n62B-2an2A:
40.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 GLY A  64
TRP A 234
VAL A 296
 HEM  A 901 ( 3.9A)
HEM  A 901 ( 3.6A)
None
 0.30A 3n65B-2an2A:
48.8		 3n65B-2an2A:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 GLY A  64
TRP A 234
VAL A 296
 HEM  A 901 ( 3.9A)
HEM  A 901 ( 3.6A)
None
 0.27A 3n66B-2an2A:
14.4		 3n66B-2an2A:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ARG A  57
ARG A  65
TRP A  68
 None
 1.50A 4b7nA-2an2A:
undetectable		 4b7nA-2an2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ARG A  57
ARG A  65
TRP A  68
 None
 1.48A 4cpzG-2an2A:
undetectable		 4cpzG-2an2A:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ARG A 243
THR A 324
TRP A 325
 H4B  A 903 (-3.4A)
None
H4B  A 903 ( 3.6A)
 0.26A 4d7hA-2an2A:
55.4		 4d7hA-2an2A:
93.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.89A 4fzvA-2an2A:
undetectable		 4fzvA-2an2A:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 6 ARG A 128
GLU A 239
ARG A 243
ASP A 247
ARG A 250
 ARG  A2000 (-4.0A)
ARG  A2000 ( 3.1A)
H4B  A 903 (-3.4A)
None
None
 0.54A 4kcnA-2an2A:
48.5		 4kcnA-2an2A:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 6 ARG A 128
GLU A 239
ARG A 243
ASP A 247
ARG A 250
 ARG  A2000 (-4.0A)
ARG  A2000 ( 3.1A)
H4B  A 903 (-3.4A)
None
None
 0.55A 4kcnB-2an2A:
48.5		 4kcnB-2an2A:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 8 ARG A 340
TYR A 342
GLU A 313
ARG A  65
 None
 1.37A 4kr4C-2an2A:
undetectable		 4kr4C-2an2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 10 ALA A 283
ILE A 198
VAL A 260
ALA A 276
ILE A 261
 None
 1.07A 4lbgA-2an2A:
undetectable		 4lbgA-2an2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 9 ALA A 283
ILE A 198
VAL A 260
ALA A 276
ILE A 261
 None
 1.02A 4lbgB-2an2A:
undetectable		 4lbgB-2an2A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ARG A 243
THR A 324
TRP A 325
 H4B  A 903 (-3.4A)
None
H4B  A 903 ( 3.6A)
 0.42A 4ug5A-2an2A:
49.5		 4ug5A-2an2A:
93.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ARG A 243
THR A 324
TRP A 325
 H4B  A 903 (-3.4A)
None
H4B  A 903 ( 3.6A)
 0.24A 4uglA-2an2A:
55.7		 4uglA-2an2A:
93.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ARG A 243
THR A 324
TRP A 325
 H4B  A 903 (-3.4A)
None
H4B  A 903 ( 3.6A)
 0.30A 5g6cA-2an2A:
49.9		 5g6cA-2an2A:
93.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 7 ILE A 127
ILE A 213
THR A  97
ILE A 102
 None
 0.88A 5murB-2an2A:
undetectable		 5murB-2an2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 10 LEU A  48
ILE A 106
ALA A 229
ILE A 108
TYR A 351
 None
HEM  A 901 ( 4.8A)
None
None
HEM  A 901 (-4.4A)
 1.03A 5mvmD-2an2A:
undetectable
5mvmE-2an2A:
undetectable		 5mvmD-2an2A:
12.75
5mvmE-2an2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 PHE A 163
ASP A 141
LEU A 168
 None
 0.79A 5uhbC-2an2A:
undetectable		 5uhbC-2an2A:
15.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 GLY A  64
TRP A 234
VAL A 296
 HEM  A 901 ( 3.9A)
HEM  A 901 ( 3.6A)
None
 0.26A 5vuoB-2an2A:
48.7		 5vuoB-2an2A:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.87A 5zvgA-2an2A:
undetectable		 5zvgA-2an2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		3 / 3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.89A 5zvgB-2an2A:
undetectable		 5zvgB-2an2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 5 SER A 144
ARG A 128
ASP A 141
ARG A 250
 None
ARG  A2000 (-4.0A)
None
None
 1.27A 6dwdA-2an2A:
undetectable		 6dwdA-2an2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 6 GLU A  17
ARG A  57
VAL A 221
PRO A 349
 None
 1.49A 6fgdA-2an2A:
undetectable		 6fgdA-2an2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 4 ASP A 322
ILE A 327
PRO A 328
LEU A 326
 None
 1.35A 6mkeB-2an2A:
undetectable		 6mkeB-2an2A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 10 TYR A 129
PHE A 163
ILE A 240
TRP A 208
TYR A 288
 None
 1.49A 6mkeC-2an2A:
undetectable		 6mkeC-2an2A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		4 / 4 ASP A 322
ILE A 327
PRO A 328
LEU A 326
 None
 1.29A 6mkeA-2an2A:
undetectable		 6mkeA-2an2A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS
(Bacillus
subtilis) 		5 / 10 TYR A 129
PHE A 163
ILE A 240
TRP A 208
TYR A 288
 None
 1.49A 6mkeD-2an2A:
undetectable		 6mkeD-2an2A:
13.08