SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2anc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 8 ALA A 185
TYR A 165
ILE A 182
TYR A   7
 None
 0.97A 2zm8A-2ancA:
undetectable		 2zm8A-2ancA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 8 ALA A 185
TYR A 165
ILE A 182
TYR A   7
 None
 0.99A 2zmaA-2ancA:
undetectable		 2zmaA-2ancA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		3 / 3 ARG A 187
ARG A 196
ILE A 183
 None
 0.95A 4b7qA-2ancA:
undetectable		 4b7qA-2ancA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		3 / 3 ARG A 187
ARG A 196
ILE A 183
 None
 0.87A 4b7qC-2ancA:
undetectable		 4b7qC-2ancA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 8 LEU A  24
VAL A   9
VAL A  35
TYR A   7
 None
 0.93A 4puoC-2ancA:
undetectable		 4puoC-2ancA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 8 LEU A  24
VAL A   9
VAL A  35
TYR A   7
 None
 0.96A 4pwdA-2ancA:
undetectable		 4pwdA-2ancA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 8 LEU A 166
LEU A 179
ILE A 121
PHE A 172
 None
 0.75A 4r38A-2ancA:
undetectable		 4r38A-2ancA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 8 LEU A 166
LEU A 179
ILE A 121
PHE A 172
 None
 0.72A 4r38D-2ancA:
undetectable		 4r38D-2ancA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2anc GUANYLATE KINASE
(Escherichia
coli) 		4 / 7 ARG A 149
ALA A 153
ILE A 146
ALA A 147
 None
 0.99A 6ma7A-2ancA:
undetectable		 6ma7A-2ancA:
15.94