SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ani'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 HIS A  42
ILE A 235
LEU A 300
GLY A 194
VAL A 186
 None
 1.12A 1axwA-2aniA:
undetectable		 1axwA-2aniA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 HIS A 230
ILE A  96
ALA A  39
TYR A 112
GLU A 120
 FE  A 347 (-3.3A)
None
None
None
FE  A 347 ( 2.4A)
 1.10A 1ki7A-2aniA:
undetectable		 1ki7A-2aniA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 HIS A 230
ILE A  96
ALA A 109
TYR A 112
GLU A 120
 FE  A 347 (-3.3A)
None
None
None
FE  A 347 ( 2.4A)
 1.07A 1ki7A-2aniA:
undetectable		 1ki7A-2aniA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 HIS A 230
ILE A  96
ALA A  39
TYR A 112
GLU A 120
 FE  A 347 (-3.3A)
None
None
None
FE  A 347 ( 2.4A)
 1.14A 1ki7B-2aniA:
2.0		 1ki7B-2aniA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 HIS A 230
ILE A  96
ALA A 109
TYR A 112
GLU A 120
 FE  A 347 (-3.3A)
None
None
None
FE  A 347 ( 2.4A)
 0.85A 1ki7B-2aniA:
2.0		 1ki7B-2aniA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		7 / 11 GLU A 120
HIS A 123
GLU A 193
TYR A 198
PHE A 201
ILE A 223
GLU A 227
 FE  A 347 ( 2.4A)
FE  A 348 (-3.5A)
FE  A 347 (-2.7A)
None
None
None
FE  A 347 ( 2.1A)
 0.47A 1rnrA-2aniA:
35.7		 1rnrA-2aniA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		8 / 12 GLU A 120
HIS A 123
TYR A 127
GLU A 193
TYR A 198
PHE A 201
ILE A 223
GLU A 227
 FE  A 347 ( 2.4A)
FE  A 348 (-3.5A)
None
FE  A 347 (-2.7A)
None
None
None
FE  A 347 ( 2.1A)
 0.36A 1rnrB-2aniA:
36.1		 1rnrB-2aniA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 GLU A 227
HIS A 230
TYR A 189
GLU A  89
GLU A 120
 FE  A 347 ( 2.1A)
FE  A 347 (-3.3A)
None
FE  A 348 (-2.2A)
FE  A 347 ( 2.4A)
 0.98A 1rnrB-2aniA:
36.1		 1rnrB-2aniA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 8 PHE A 197
GLU A 120
GLN A 116
TYR A 189
 FE  A 348 ( 4.9A)
FE  A 347 ( 2.4A)
None
None
 1.44A 2aoxA-2aniA:
undetectable		 2aoxA-2aniA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 8 PHE A 233
LEU A 113
TYR A 112
LEU A 185
 None
 0.97A 2bfpB-2aniA:
undetectable		 2bfpB-2aniA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 11 ILE A 100
LEU A  20
LEU A 185
ILE A 241
THR A 172
 None
 1.39A 3a50B-2aniA:
undetectable		 3a50B-2aniA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 9 ASP A 236
ILE A 238
GLY A 194
ILE A 195
ILE A 303
 None
 0.99A 3nu4A-2aniA:
undetectable		 3nu4A-2aniA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 6 TYR A 220
GLN A 219
MET A  58
ILE A 216
 None
 1.31A 3pmzD-2aniA:
undetectable		 3pmzD-2aniA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 9 ASP A 236
ILE A 238
GLY A 194
ILE A 195
ILE A 303
 None
 1.00A 3s43A-2aniA:
undetectable		 3s43A-2aniA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 9 ILE A 238
GLY A 194
ILE A 195
ILE A 257
ILE A 303
 None
 0.93A 3s43A-2aniA:
undetectable		 3s43A-2aniA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 11 LEU A 305
GLY A 194
ILE A 195
ILE A 257
ILE A 303
 None
 1.14A 3s53B-2aniA:
undetectable		 3s53B-2aniA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 ASN A 239
ILE A 235
ILE A 238
GLY A 304
VAL A 186
 None
 0.97A 4nkvA-2aniA:
undetectable		 4nkvA-2aniA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 ASN A 239
ILE A 235
ILE A 238
GLY A 304
VAL A 186
 None
 1.00A 4nkxA-2aniA:
undetectable		 4nkxA-2aniA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 GLY A 279
ASP A  73
VAL A 202
ARG A 278
ILE A 269
 None
 0.90A 4q5mA-2aniA:
undetectable		 4q5mA-2aniA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 12 GLY A 279
ASP A  73
VAL A 202
ARG A 278
ILE A 289
 None
 0.92A 4q5mA-2aniA:
undetectable		 4q5mA-2aniA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 8 PHE A  84
PHE A  85
GLY A 194
ILE A 295
 None
 0.98A 4qogA-2aniA:
undetectable
4qogB-2aniA:
undetectable		 4qogA-2aniA:
20.40
4qogB-2aniA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 8 LEU A 224
GLU A 120
GLU A  89
ALA A  88
 None
FE  A 347 ( 2.4A)
FE  A 348 (-2.2A)
None
 0.80A 4rjdA-2aniA:
undetectable
4rjdB-2aniA:
undetectable		 4rjdA-2aniA:
10.98
4rjdB-2aniA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 6 LEU A  20
LYS A  18
GLU A 108
TYR A  36
 None
 1.06A 4z4gA-2aniA:
undetectable		 4z4gA-2aniA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 6 ILE A 241
GLY A 304
ILE A 238
TRP A 249
 None
 1.00A 5j4nB-2aniA:
undetectable		 5j4nB-2aniA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		3 / 3 VAL A 175
GLU A 256
GLU A 252
 None
 0.77A 5jsdB-2aniA:
undetectable
5jsdC-2aniA:
undetectable		 5jsdB-2aniA:
17.79
5jsdC-2aniA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 10 TYR A 222
ILE A  56
MET A  58
TYR A 220
ILE A 216
 None
 1.34A 5mzrA-2aniA:
3.6		 5mzrA-2aniA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 10 TYR A 222
ILE A  56
MET A  58
TYR A 220
ILE A 216
 None
 1.36A 5mzrC-2aniA:
3.6		 5mzrC-2aniA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		5 / 9 TYR A 222
ILE A  56
MET A  58
TYR A 220
ILE A 216
 None
 1.34A 5mzrD-2aniA:
3.6		 5mzrD-2aniA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		3 / 3 GLU A 180
HIS A 103
VAL A 165
 None
 0.77A 5trqB-2aniA:
undetectable		 5trqB-2aniA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 7 THR A 126
LEU A 205
ASN A  81
GLU A  74
 None
 1.08A 5tudA-2aniA:
undetectable		 5tudA-2aniA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		4 / 6 ASN A  22
THR A 172
ILE A 241
GLU A 244
 None
 1.15A 5uigA-2aniA:
2.7		 5uigA-2aniA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		3 / 3 LEU A  20
ILE A 241
TYR A 189
 None
 0.67A 5uunB-2aniA:
undetectable		 5uunB-2aniA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		3 / 3 VAL A  92
TYR A 188
GLU A 227
 None
None
FE  A 347 ( 2.1A)
 0.73A 5zmqD-2aniA:
undetectable
5zmqE-2aniA:
undetectable		 5zmqD-2aniA:
20.18
5zmqE-2aniA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT
(Chlamydia
trachomatis) 		3 / 3 ARG A  76
LEU A  80
PHE A  84
 None
 0.50A 6nknP-2aniA:
5.7		 6nknP-2aniA:
19.25