SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2anu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		5 / 9 PHE A  12
SER A  41
GLY A  95
ALA A 134
LEU A 135
 None
 1.40A 1jb0A-2anuA:
undetectable		 1jb0A-2anuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		5 / 12 GLY A  21
ASN A 173
GLU A 170
ILE A 137
HIS A 106
 None
CL  A1002 ( 4.7A)
None
None
ZN  A 705 (-3.3A)
 1.14A 1kxhA-2anuA:
3.2		 1kxhA-2anuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 ASP A  20
HIS A  15
HIS A  45
 ZN  A 505 (-2.0A)
ZN  A 405 (-3.4A)
ZN  A 505 ( 3.4A)
 0.68A 1oe1A-2anuA:
undetectable		 1oe1A-2anuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 ASP A  20
HIS A  15
HIS A  45
 ZN  A 505 (-2.0A)
ZN  A 405 (-3.4A)
ZN  A 505 ( 3.4A)
 0.68A 1oe3A-2anuA:
undetectable		 1oe3A-2anuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 4 HIS A  45
GLU A  97
HIS A  15
HIS A 195
 ZN  A 505 ( 3.4A)
ZN  A 405 ( 2.7A)
ZN  A 405 (-3.4A)
ZN  A 505 (-3.4A)
 1.25A 1uttA-2anuA:
undetectable		 1uttA-2anuA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 4 HIS A  45
GLU A  97
HIS A  15
HIS A 195
 ZN  A 505 ( 3.4A)
ZN  A 405 ( 2.7A)
ZN  A 405 (-3.4A)
ZN  A 505 (-3.4A)
 1.16A 2ow9B-2anuA:
undetectable		 2ow9B-2anuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 4 HIS A  45
GLU A  97
HIS A  15
HIS A 195
 ZN  A 505 ( 3.4A)
ZN  A 405 ( 2.7A)
ZN  A 405 (-3.4A)
ZN  A 505 (-3.4A)
 1.20A 2ozrE-2anuA:
undetectable		 2ozrE-2anuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 VAL A  29
ASP A  30
GLU A  80
 None
 0.43A 2qeuA-2anuA:
undetectable		 2qeuA-2anuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 VAL A  29
ASP A  30
GLU A  80
 None
 0.42A 2qeuC-2anuA:
undetectable		 2qeuC-2anuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 ASP A  20
HIS A  15
HIS A  45
 ZN  A 505 (-2.0A)
ZN  A 405 (-3.4A)
ZN  A 505 ( 3.4A)
 0.69A 2xxgA-2anuA:
undetectable		 2xxgA-2anuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		5 / 12 HIS A  45
ASP A  20
HIS A 195
ASP A 193
LEU A  77
 ZN  A 505 ( 3.4A)
ZN  A 505 (-2.0A)
ZN  A 505 (-3.4A)
ZN  A 605 (-2.4A)
None
 1.48A 3lmyA-2anuA:
4.6		 3lmyA-2anuA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		5 / 9 PHE A  12
SER A  41
GLY A  95
ALA A 134
LEU A 135
 None
 1.40A 3pcqA-2anuA:
undetectable		 3pcqA-2anuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 7 ASN A 101
ASP A 193
HIS A 195
HIS A  15
 None
ZN  A 605 (-2.4A)
ZN  A 505 (-3.4A)
ZN  A 405 (-3.4A)
 1.09A 3t01A-2anuA:
undetectable		 3t01A-2anuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 8 SER A 192
ASP A  11
GLU A 170
THR A  16
 None
 1.07A 4lnwA-2anuA:
undetectable		 4lnwA-2anuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		5 / 11 HIS A  15
SER A  19
THR A  99
ARG A  55
ALA A  64
 ZN  A 405 (-3.4A)
None
None
None
None
 1.46A 4qvpV-2anuA:
undetectable
4qvpb-2anuA:
undetectable		 4qvpV-2anuA:
20.74
4qvpb-2anuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		5 / 11 HIS A  15
SER A  19
THR A  99
ARG A  55
ALA A  64
 ZN  A 405 (-3.4A)
None
None
None
None
 1.46A 4qvpH-2anuA:
undetectable
4qvpN-2anuA:
undetectable		 4qvpH-2anuA:
20.74
4qvpN-2anuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 8 THR A  51
ILE A  46
LEU A 104
VAL A 122
 None
 0.89A 4r38B-2anuA:
undetectable		 4r38B-2anuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 8 THR A  51
ILE A  46
LEU A 104
VAL A 122
 None
 0.88A 4r38D-2anuA:
undetectable		 4r38D-2anuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 6 GLY A  95
SER A  41
VAL A 110
HIS A  13
 None
None
None
ZN  A 405 ( 3.3A)
 1.12A 5ewuA-2anuA:
undetectable		 5ewuA-2anuA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 6 GLY A  95
SER A  41
VAL A 110
HIS A  13
 None
None
None
ZN  A 405 ( 3.3A)
 1.12A 5ewuB-2anuA:
undetectable		 5ewuB-2anuA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 HIS A 195
ASP A  20
HIS A  45
 ZN  A 505 (-3.4A)
ZN  A 505 (-2.0A)
ZN  A 505 ( 3.4A)
 0.44A 5oexA-2anuA:
undetectable		 5oexA-2anuA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 HIS A 195
ASP A  20
HIS A  45
 ZN  A 505 (-3.4A)
ZN  A 505 (-2.0A)
ZN  A 505 ( 3.4A)
 0.39A 5oexB-2anuA:
undetectable		 5oexB-2anuA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 HIS A 195
ASP A  20
HIS A  45
 ZN  A 505 (-3.4A)
ZN  A 505 (-2.0A)
ZN  A 505 ( 3.4A)
 0.36A 5oexC-2anuA:
undetectable		 5oexC-2anuA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		3 / 3 HIS A 195
ASP A  20
HIS A  45
 ZN  A 505 (-3.4A)
ZN  A 505 (-2.0A)
ZN  A 505 ( 3.4A)
 0.35A 5oexD-2anuA:
undetectable		 5oexD-2anuA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2anu HYPOTHETICAL PROTEIN
TM0559
(Thermotoga
maritima) 		4 / 8 HIS A  13
ASP A  48
THR A  99
LEU A  52
 ZN  A 405 ( 3.3A)
None
None
None
 1.16A 5x19A-2anuA:
undetectable
5x19C-2anuA:
undetectable
5x19P-2anuA:
undetectable		 5x19A-2anuA:
17.44
5x19C-2anuA:
21.20
5x19P-2anuA:
21.20