SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ap2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ap2 SINGLE CHAIN FV
(Mus
musculus) 		4 / 8 GLY A  16
ILE A  81
VAL A  19
VAL A  13
 None
 0.80A 3fi0I-2ap2A:
undetectable		 3fi0I-2ap2A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2ap2 SINGLE CHAIN FV
(Mus
musculus) 		4 / 5 TYR A  42
GLN A  95
LEU A 102
PHE A 104
 None
 0.45A 3ls4L-2ap2A:
20.3		 3ls4L-2ap2A:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2ap2 SINGLE CHAIN FV
(Mus
musculus) 		4 / 6 GLY A 105
TYR A  92
ALA A 106
TYR A  93
 None
 1.00A 4ae1A-2ap2A:
3.0		 4ae1A-2ap2A:
undetectable