SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ap9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  98
ASP A 101
ARG A 104
MET A 105
 None
 1.02A 1dtlA-2ap9A:
undetectable		 1dtlA-2ap9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 292
GLU A 233
ALA A 268
LEU A 212
 None
 1.20A 1eta1-2ap9A:
undetectable		 1eta1-2ap9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 292
GLU A 233
ALA A 268
LEU A 212
 None
 1.17A 1etb1-2ap9A:
undetectable		 1etb1-2ap9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		3 / 4 LYS A 253
ALA A 256
MET A 213
 None
 1.07A 1hk3A-2ap9A:
undetectable		 1hk3A-2ap9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 215
GLU A 282
ASP A 286
 None
 0.76A 1nt2A-2ap9A:
4.1		 1nt2A-2ap9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 292
GLU A 233
ALA A 268
LEU A 212
 None
 1.08A 1sn5A-2ap9A:
undetectable		 1sn5A-2ap9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 212
VAL A  67
ILE A 119
VAL A  33
VAL A  35
 None
 1.02A 2nnpB-2ap9A:
undetectable		 2nnpB-2ap9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 142
ILE A 193
VAL A 156
HIS A 191
 None
 1.42A 3deuA-2ap9A:
0.0		 3deuA-2ap9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB302_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 142
ILE A 193
VAL A 156
HIS A 191
 None
 1.35A 3deuB-2ap9A:
0.0		 3deuB-2ap9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 189
ASP A 185
THR A  96
PRO A  97
ILE A 193
 None
 1.43A 4eb6B-2ap9A:
undetectable
4eb6C-2ap9A:
2.2		 4eb6B-2ap9A:
20.70
4eb6C-2ap9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 176
PRO A 177
VAL A  32
GLU A 282
ALA A 260
 None
 0.99A 5igtA-2ap9A:
undetectable		 5igtA-2ap9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A  68
LYS A  36
VAL A 159
ASN A 192
 None
 1.39A 5vc3A-2ap9A:
undetectable		 5vc3A-2ap9A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2ap9 ACETYLGLUTAMATE
KINASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 100
VAL A 189
ASP A 185
 None
 0.62A 5x23A-2ap9A:
undetectable		 5x23A-2ap9A:
19.84