SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2apj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		4 / 7 GLY A 150
ARG A 146
ILE A 152
GLY A 114
 None
 0.85A 11gsB-2apjA:
undetectable		 11gsB-2apjA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		3 / 3 ALA A  34
VAL A  92
TRP A  50
 SEB  A  31 ( 3.8A)
None
None
 0.98A 1gmkC-2apjA:
undetectable
1gmkD-2apjA:
undetectable		 1gmkC-2apjA:
6.17
1gmkD-2apjA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		3 / 3 ALA A  34
VAL A  92
TRP A  50
 SEB  A  31 ( 3.8A)
None
None
 0.89A 1kqeB-2apjA:
undetectable
1kqeD-2apjA:
undetectable		 1kqeB-2apjA:
7.00
1kqeD-2apjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		3 / 3 HIS A 186
VAL A 155
LEU A 193
 None
 0.75A 4m2vA-2apjA:
undetectable		 4m2vA-2apjA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		4 / 5 PRO A  79
GLY A  35
ASP A  70
ASP A  85
 None
SEB  A  31 ( 3.5A)
None
None
 1.02A 4n48B-2apjA:
undetectable		 4n48B-2apjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  95
GLY A  93
ILE A  64
LEU A 251
LEU A 115
 None
 1.14A 5bw4A-2apjA:
undetectable		 5bw4A-2apjA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		5 / 12 TYR A 255
ALA A 101
ILE A 196
LEU A 156
PRO A 194
 None
 1.16A 6b3bA-2apjA:
3.0		 6b3bA-2apjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 2apj PUTATIVE ESTERASE
(Arabidopsis
thaliana) 		3 / 3 TRP A  73
ILE A  24
GLU A 143
 None
 0.87A 6hcxA-2apjA:
undetectable		 6hcxA-2apjA:
12.40