SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2apn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		5 / 11 GLY A  40
GLY A  41
ILE A  37
TYR A  36
LEU A  69
 None
 1.15A 1p91A-2apnA:
undetectable		 1p91A-2apnA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 LYS A  18
LEU A  33
ALA A  15
THR A  12
 None
 1.23A 1tyrA-2apnA:
undetectable		 1tyrA-2apnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		5 / 9 ALA A  15
LEU A  33
VAL A  84
ILE A  71
LEU A  79
 None
 1.37A 3fl9D-2apnA:
undetectable		 3fl9D-2apnA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		5 / 12 GLN A  46
GLY A  44
GLY A  39
ALA A 102
ASN A  99
 None
 1.08A 3t7sB-2apnA:
undetectable		 3t7sB-2apnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 LYS A  18
LEU A  33
ALA A  15
THR A  12
 None
 1.24A 4d7bB-2apnA:
undetectable		 4d7bB-2apnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 ILE A  80
GLN A  77
ILE A  71
ASP A  72
 None
 1.20A 4w5qA-2apnA:
undetectable		 4w5qA-2apnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 ILE A  80
GLN A  77
ILE A  71
ASP A  72
 None
 1.16A 4w5tA-2apnA:
undetectable		 4w5tA-2apnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 ILE A  80
GLN A  77
ILE A  71
ASP A  72
 None
 1.19A 4z4cA-2apnA:
undetectable		 4z4cA-2apnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 ILE A  80
GLN A  77
ILE A  71
ASP A  72
 None
 1.22A 4z4dA-2apnA:
undetectable		 4z4dA-2apnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 LYS A  18
LEU A  33
ALA A  15
THR A  12
 None
 1.26A 5l4iB-2apnA:
undetectable		 5l4iB-2apnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		4 / 6 ILE A  80
GLN A  77
ILE A  71
ASP A  72
 None
 1.18A 6cbdA-2apnA:
undetectable		 6cbdA-2apnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2apn PROTEIN HI1723
(Haemophilus
influenzae) 		5 / 12 ASN A  98
THR A  38
ILE A  37
PHE A  49
PHE A  95
 None
 1.26A 6j20A-2apnA:
undetectable		 6j20A-2apnA:
11.90