SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2apo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 187
ALA A 119
HIS A 116
THR A 192
 None
 0.89A 1c9sT-2apoA:
undetectable
1c9sU-2apoA:
undetectable		 1c9sT-2apoA:
12.32
1c9sU-2apoA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
RIBOSOME BIOGENESIS
PROTEIN NOP10
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 214
ASP A  51
GLY A  86
MET B 406
TYR B 415
 None
 1.30A 1t69A-2apoA:
undetectable		 1t69A-2apoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 292
GLU A 288
ASN A  33
 None
 0.72A 1zq9A-2apoA:
undetectable		 1zq9A-2apoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 272
ILE A 279
ALA A 300
ALA A 315
VAL A 267
 None
 1.09A 2qhfA-2apoA:
undetectable		 2qhfA-2apoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  68
LEU A 218
LEU A  92
PRO A  53
 None
 0.75A 3ozwA-2apoA:
undetectable		 3ozwA-2apoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 261
LYS A 274
ILE A 272
GLY A 292
 None
 0.89A 4hb6A-2apoA:
undetectable		 4hb6A-2apoA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 261
LYS A 274
ILE A 272
GLY A 292
 None
 0.84A 4hb8A-2apoA:
undetectable		 4hb8A-2apoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 258
ILE A 261
LEU A 245
LEU A 286
 None
 0.84A 4l1wA-2apoA:
undetectable		 4l1wA-2apoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 4 VAL A 252
THR A 289
GLU A 288
GLU A 242
 None
 1.18A 4l78A-2apoA:
2.5		 4l78A-2apoA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 159
PHE A 128
ALA A 119
ALA A 194
ILE A 186
 None
 0.92A 4nkxB-2apoA:
undetectable		 4nkxB-2apoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 159
PHE A 128
ALA A 119
ALA A 194
ILE A 186
 None
 0.90A 4nkxC-2apoA:
undetectable		 4nkxC-2apoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 159
PHE A 128
ALA A 119
ALA A 194
ILE A 186
 None
 0.87A 4nkxD-2apoA:
undetectable		 4nkxD-2apoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 258
ILE A 261
LEU A 245
LEU A 286
 None
 0.89A 4xo7A-2apoA:
undetectable		 4xo7A-2apoA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
RIBOSOME BIOGENESIS
PROTEIN NOP10
(Methanocaldococc
us
jannaschii) 		3 / 3 THR B 428
HIS A 114
LEU A 112
 None
 0.85A 5axdC-2apoB:
undetectable		 5axdC-2apoB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  80
TYR A 109
SER A 204
 None
None
K  A 503 (-2.8A)
 0.63A 5iktA-2apoA:
undetectable		 5iktA-2apoA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
RIBOSOME BIOGENESIS
PROTEIN NOP10
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 209
VAL A 110
GLY B 413
LEU B 414
 None
 1.08A 5syjA-2apoA:
undetectable		 5syjA-2apoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 207
HIS A 247
PRO A 105
ILE A 104
 None
 1.09A 5vkqA-2apoA:
undetectable
5vkqB-2apoA:
undetectable		 5vkqA-2apoA:
12.35
5vkqB-2apoA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 8 PHE A 207
HIS A 247
PRO A 105
ILE A 104
 None
 1.06A 5vkqB-2apoA:
undetectable
5vkqC-2apoA:
undetectable		 5vkqB-2apoA:
12.35
5vkqC-2apoA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 207
HIS A 247
PRO A 105
ILE A 104
 None
 1.06A 5vkqC-2apoA:
undetectable
5vkqD-2apoA:
undetectable		 5vkqC-2apoA:
12.35
5vkqD-2apoA:
12.35