SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 ALA A 248
GLY A 268
ILE A 269
ILE A 264
 None
SO4  A2002 ( 4.9A)
None
None
 0.69A 1hshD-2aqwA:
undetectable		 1hshD-2aqwA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 THR A 166
PHE A 242
MET A 220
LEU A 176
 None
 1.03A 1lhvA-2aqwA:
undetectable		 1lhvA-2aqwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 6 ASN A  95
ASN A  51
ILE A  55
GLY A  54
 None
 1.00A 1oniA-2aqwA:
undetectable
1oniB-2aqwA:
undetectable		 1oniA-2aqwA:
17.15
1oniB-2aqwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 6 ASN A  95
ASN A  51
ILE A  55
GLY A  54
 None
 1.05A 1oniD-2aqwA:
undetectable
1oniF-2aqwA:
undetectable		 1oniD-2aqwA:
17.15
1oniF-2aqwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.13A 1p6kA-2aqwA:
undetectable		 1p6kA-2aqwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.14A 1p6kB-2aqwA:
undetectable		 1p6kB-2aqwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.13A 1rs6A-2aqwA:
undetectable		 1rs6A-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.11A 1rs6B-2aqwA:
undetectable		 1rs6B-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.15A 1rs7B-2aqwA:
undetectable		 1rs7B-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		3 / 3 LYS A 196
ILE A 264
THR A 166
 None
 0.54A 1rx3A-2aqwA:
undetectable		 1rx3A-2aqwA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.15A 1zzqA-2aqwA:
undetectable		 1zzqA-2aqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.15A 1zzqB-2aqwA:
undetectable		 1zzqB-2aqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.13A 1zzuA-2aqwA:
undetectable		 1zzuA-2aqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.13A 1zzuB-2aqwA:
undetectable		 1zzuB-2aqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		6 / 12 ALA A 221
VAL A 244
ILE A 264
GLY A 241
ILE A 240
ILE A 195
 None
 1.38A 2avvB-2aqwA:
undetectable		 2avvB-2aqwA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 6 LEU A  18
TYR A 312
ILE A 299
GLY A 268
 None
None
None
SO4  A2002 ( 4.9A)
 0.90A 2du8A-2aqwA:
undetectable		 2du8A-2aqwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 6 LEU A  18
TYR A 312
ILE A 299
GLY A 268
 None
None
None
SO4  A2002 ( 4.9A)
 0.93A 2du8B-2aqwA:
undetectable		 2du8B-2aqwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 7 LEU A  66
PHE A  86
PHE A  91
ILE A  59
 None
 0.83A 2opxA-2aqwA:
undetectable		 2opxA-2aqwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		6 / 12 ALA A 221
VAL A 244
ILE A 264
GLY A 241
ILE A 240
ILE A 195
 None
 1.42A 2q63A-2aqwA:
undetectable		 2q63A-2aqwA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		6 / 12 ALA A 221
VAL A 244
ILE A 264
GLY A 241
ILE A 240
ILE A 195
 None
 1.43A 2q64B-2aqwA:
undetectable		 2q64B-2aqwA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		6 / 12 ALA A 221
VAL A 244
ILE A 264
GLY A 241
ILE A 240
ILE A 195
 None
 1.43A 2qakA-2aqwA:
undetectable		 2qakA-2aqwA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		5 / 11 ILE A 319
ASN A 273
LEU A 280
ILE A 293
THR A  16
 None
 1.37A 3a50B-2aqwA:
undetectable		 3a50B-2aqwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.15A 3n62B-2aqwA:
undetectable		 3n62B-2aqwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.33A 3n66B-2aqwA:
undetectable		 3n66B-2aqwA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 7 LEU A 194
GLY A 241
ALA A 191
PHE A 239
 None
 0.99A 3tehB-2aqwA:
undetectable		 3tehB-2aqwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		6 / 12 ALA A 221
VAL A 244
ILE A 264
GLY A 241
ILE A 240
ILE A 195
 None
 1.48A 3tl9B-2aqwA:
undetectable		 3tl9B-2aqwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		3 / 3 LYS A 196
ILE A 264
THR A 166
 None
 0.55A 4gh8A-2aqwA:
undetectable		 4gh8A-2aqwA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 7 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.35A 4kcnB-2aqwA:
undetectable		 4kcnB-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 6 LEU A 194
MET A 137
LEU A 265
ILE A 255
 None
 0.96A 4okxA-2aqwA:
undetectable		 4okxA-2aqwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 VAL A 244
GLY A 241
SER A 262
ARG A 256
 None
 0.83A 5e26C-2aqwA:
2.2
5e26D-2aqwA:
undetectable		 5e26C-2aqwA:
20.31
5e26D-2aqwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		4 / 8 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.34A 5vuoB-2aqwA:
undetectable		 5vuoB-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE
(Plasmodium
yoelii) 		5 / 11 ASN A  87
THR A 136
PHE A 126
ILE A 119
MET A 106
 None
 1.50A 6hcoA-2aqwA:
1.4
6hcoB-2aqwA:
undetectable		 6hcoA-2aqwA:
17.80
6hcoB-2aqwA:
17.80