SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ar1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GMK_C_DVAC6_0 (GRAMICIDIN A)	2ar1	HYPOTHETICAL PROTEIN (Leishmania major)	3 / 3	ALA A 148 VAL A 146 TRP A 14	None	0.97A	1gmkC-2ar1A: undetectable 1gmkD-2ar1A: undetectable	1gmkC-2ar1A: 15.49 1gmkD-2ar1A: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VT7_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	2ar1	HYPOTHETICAL PROTEIN (Leishmania major)	5 / 12	TYR A 92 VAL A 143 SER A 142 SER A 18 VAL A 109	GOL A 301 (-4.7A) None None GOL A 301 (-3.6A) None	1.35A	3vt7A-2ar1A: undetectable	3vt7A-2ar1A: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_1 (HYDROXYINDOLE O-METHYLTRANSFERASE)	2ar1	HYPOTHETICAL PROTEIN (Leishmania major)	3 / 3	TYR A 42 ASP A 94 ASP A 81	None	0.81A	4a6eA-2ar1A: undetectable	4a6eA-2ar1A: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P7N_A_GCSA702_1 (POLY-BETA-1,6-N-ACET YL-D-GLUCOSAMINE N-DEACETYLASE)	2ar1	HYPOTHETICAL PROTEIN (Leishmania major)	3 / 3	ASP A 37 TYR A 92 TRP A 36	GOL A 301 (-3.6A) GOL A 301 (-4.7A) GOL A 301 (-3.8A)	1.29A	4p7nA-2ar1A: undetectable	4p7nA-2ar1A: 18.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GMK_C_DVAC6_0","GRAMICIDIN A","2ar1","HYPOTHETICAL PROTEIN","Leishmania major",3,"ALA A 148;VAL A 146;TRP A  14","None","0.97A","1gmkC-2ar1A:undetectable;1gmkD-2ar1A:undetectable","1gmkC-2ar1A:15.49;1gmkD-2ar1A:15.49"],["3VT7_A_VDXA500_1","VITAMIN D3 RECEPTOR","2ar1","HYPOTHETICAL PROTEIN","Leishmania major",5,"TYR A  92;VAL A 143;SER A 142;SER A  18;VAL A 109","GOL A 301 (-4.7A);None;None;GOL A 301 (-3.6A);None","1.35A","3vt7A-2ar1A:undetectable","3vt7A-2ar1A:23.28"],["4A6E_A_SAMA1349_1","HYDROXYINDOLE O-METHYLTRANSFERASE","2ar1","HYPOTHETICAL PROTEIN","Leishmania major",3,"TYR A  42;ASP A  94;ASP A  81","None","0.81A","4a6eA-2ar1A:undetectable","4a6eA-2ar1A:19.89"],["4P7N_A_GCSA702_1","POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE N-DEACETYLASE","2ar1","HYPOTHETICAL PROTEIN","Leishmania major",3,"ASP A  37;TYR A  92;TRP A  36","GOL A 301 (-3.6A);GOL A 301 (-4.7A);GOL A 301 (-3.8A)","1.29A","4p7nA-2ar1A:undetectable","4p7nA-2ar1A:18.92"]]