SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2arc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.43A 2cmlA-2arcA:
undetectable		 2cmlA-2arcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.36A 2cmlB-2arcA:
undetectable		 2cmlB-2arcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.34A 2cmlC-2arcA:
undetectable		 2cmlC-2arcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.37A 2cmlD-2arcA:
undetectable		 2cmlD-2arcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.46A 3ticD-2arcA:
undetectable		 3ticD-2arcA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.44A 4mwrA-2arcA:
undetectable		 4mwrA-2arcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 101
TRP A 104
ILE A 153
 None
 1.03A 4mwxA-2arcA:
undetectable		 4mwxA-2arcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_2
(NEURAMINIDASE)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.45A 5l17A-2arcA:
undetectable		 5l17A-2arcA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 GLU A  90
ARG A  52
TYR A  92
 None
 0.65A 5trqB-2arcA:
3.0		 5trqB-2arcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 10 PRO A 100
ALA A  21
GLY A 135
ILE A 138
ALA A 152
 None
 1.35A 5vyhA-2arcA:
undetectable		 5vyhA-2arcA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2arc ARABINOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 VAL A  96
PHE A 130
SER A 131
LEU A 133
ILE A 137
 None
 0.74A 6fdyU-2arcA:
undetectable		 6fdyU-2arcA:
22.66