SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2arf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2arf WILSON DISEASE
ATPASE
(Homo
sapiens) 		4 / 7 LEU A1057
VAL A1060
GLY A1061
ILE A1192
 None
 0.82A 1p2yA-2arfA:
undetectable		 1p2yA-2arfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2arf WILSON DISEASE
ATPASE
(Homo
sapiens) 		4 / 8 ASP A1185
ILE A1184
VAL A1056
VAL A1059
 None
 0.80A 3fi0B-2arfA:
undetectable		 3fi0B-2arfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2arf WILSON DISEASE
ATPASE
(Homo
sapiens) 		4 / 8 ASP A1185
ILE A1184
VAL A1056
VAL A1059
 None
 0.81A 3fi0I-2arfA:
undetectable		 3fi0I-2arfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2arf WILSON DISEASE
ATPASE
(Homo
sapiens) 		4 / 5 ILE A1194
GLY A1072
ILE A1180
LEU A1071
 None
 0.84A 5dzkB-2arfA:
undetectable
5dzkI-2arfA:
undetectable
5dzkW-2arfA:
undetectable		 5dzkB-2arfA:
25.00
5dzkI-2arfA:
22.22
5dzkW-2arfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2arf WILSON DISEASE
ATPASE
(Homo
sapiens) 		4 / 5 ILE A1194
GLY A1072
ILE A1180
LEU A1071
 None
 0.86A 5dzki-2arfA:
undetectable
5dzkj-2arfA:
undetectable
5dzkx-2arfA:
undetectable		 5dzki-2arfA:
22.22
5dzkj-2arfA:
22.22
5dzkx-2arfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2arf WILSON DISEASE
ATPASE
(Homo
sapiens) 		4 / 4 ILE A1194
GLY A1072
ILE A1180
LEU A1071
 None
 0.85A 5dzkl-2arfA:
undetectable
5dzkz-2arfA:
undetectable		 5dzkl-2arfA:
22.22
5dzkz-2arfA:
15.38