SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2arh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		5 / 10 PHE A 172
GLY A 177
ARG A 191
GLU A 110
LEU A 184
 None
 1.00A 1cmcA-2arhA:
undetectable
1cmcB-2arhA:
undetectable		 1cmcA-2arhA:
21.43
1cmcB-2arhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		5 / 10 ARG A 191
GLU A 110
LEU A 184
PHE A 172
GLY A 177
 None
 1.02A 1cmcA-2arhA:
undetectable
1cmcB-2arhA:
undetectable		 1cmcA-2arhA:
21.43
1cmcB-2arhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		5 / 11 ARG A 191
GLU A 110
LEU A 184
PHE A 172
GLY A 177
 None
 1.02A 1mjqA-2arhA:
undetectable
1mjqB-2arhA:
undetectable		 1mjqA-2arhA:
21.50
1mjqB-2arhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		3 / 3 GLU A 103
GLU A  83
LEU A  42
 None
 0.64A 1v8bA-2arhA:
undetectable		 1v8bA-2arhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		3 / 3 GLU A 103
GLU A  83
LEU A  42
 None
 0.67A 1v8bB-2arhA:
undetectable		 1v8bB-2arhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		5 / 12 LEU A  24
VAL A  25
VAL A  99
PHE A  77
PHE A  78
 None
 1.29A 2y00B-2arhA:
undetectable		 2y00B-2arhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		5 / 10 ILE A  15
GLY A  79
PHE A  78
VAL A  66
LEU A  42
 None
 1.15A 3elzB-2arhA:
2.3		 3elzB-2arhA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		3 / 3 ARG A 163
GLU A 158
THR A 157
 None
 0.78A 3v4tA-2arhA:
2.7		 3v4tA-2arhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		4 / 8 SER A  17
ILE A  22
PHE A  77
GLU A  81
 None
 1.24A 4cx7A-2arhA:
undetectable
4cx7B-2arhA:
undetectable		 4cx7A-2arhA:
17.26
4cx7B-2arhA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		4 / 8 SER A  17
ILE A  22
PHE A  77
GLU A  81
 None
 1.24A 4cx7C-2arhA:
undetectable
4cx7D-2arhA:
undetectable		 4cx7C-2arhA:
17.26
4cx7D-2arhA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2arh HYPOTHETICAL PROTEIN
AQ_1966
(Aquifex
aeolicus) 		3 / 3 SER A  17
GLU A 125
GLU A 106
 None
 0.84A 4ymgB-2arhA:
undetectable		 4ymgB-2arhA:
19.84