SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ark'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 10 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 0.97A 1pxxA-2arkA:
undetectable		 1pxxA-2arkA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 0.97A 1pxxC-2arkA:
undetectable		 1pxxC-2arkA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		3 / 3 GLY A 116
ASP A  84
ASN A 114
 None
 0.48A 1vq1A-2arkA:
2.6		 1vq1A-2arkA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 11 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.12A 3n8yA-2arkA:
undetectable		 3n8yA-2arkA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		4 / 5 VAL A  75
LEU A  76
ILE A   7
ALA A  42
 None
 0.86A 3n8yB-2arkA:
undetectable		 3n8yB-2arkA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.00A 3pghC-2arkA:
undetectable		 3pghC-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.00A 3pghD-2arkA:
undetectable		 3pghD-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 0.93A 4coxC-2arkA:
undetectable		 4coxC-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		3 / 3 ARG A 157
TRP A 161
ILE A 176
 GOL  A 509 (-4.4A)
None
None
 0.87A 4mwxA-2arkA:
undetectable		 4mwxA-2arkA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.00A 4otyA-2arkA:
undetectable		 4otyA-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.00A 4otyB-2arkA:
undetectable		 4otyB-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.02A 4rrwD-2arkA:
undetectable		 4rrwD-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.02A 4rrzD-2arkA:
undetectable		 4rrzD-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 9 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.03A 4rs0A-2arkA:
undetectable		 4rs0A-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.03A 5ikqA-2arkA:
undetectable		 5ikqA-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.04A 5ikqB-2arkA:
undetectable		 5ikqB-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.10A 5ikrB-2arkA:
undetectable		 5ikrB-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 12 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 0.99A 5kirA-2arkA:
undetectable		 5kirA-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		4 / 6 GLU A 147
PHE A  91
THR A  15
PHE A 130
 None
None
PO4  A 501 (-3.2A)
None
 1.42A 5lrbA-2arkA:
undetectable		 5lrbA-2arkA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2ark FLAVODOXIN
(Aquifex
aeolicus) 		5 / 9 VAL A 162
ASP A  51
LEU A 154
ALA A  54
VAL A  55
 None
 1.22A 6c2mB-2arkA:
undetectable		 6c2mB-2arkA:
18.75