SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2arz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2arz HYPOTHETICAL PROTEIN
PA4388
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 211
GLY A 199
LEU A  14
LYS A  15
 None
 1.06A 1gtiD-2arzA:
undetectable		 1gtiD-2arzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2arz HYPOTHETICAL PROTEIN
PA4388
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 207
LEU A 208
GLY A 205
ARG A 203
 None
 1.45A 1j7kA-2arzA:
undetectable		 1j7kA-2arzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2arz HYPOTHETICAL PROTEIN
PA4388
(Pseudomonas
aeruginosa) 		4 / 8 SER A 113
PHE A 110
TYR A 106
VAL A  36
 None
None
None
GOL  A2648 ( 4.6A)
 1.09A 3jq7C-2arzA:
undetectable		 3jq7C-2arzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2arz HYPOTHETICAL PROTEIN
PA4388
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  91
TRP A 125
VAL A 126
 None
 0.35A 4w9nC-2arzA:
undetectable		 4w9nC-2arzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 2arz HYPOTHETICAL PROTEIN
PA4388
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  89
GLU A  90
LEU A  88
HIS A  57
LEU A  21
 None
 1.21A 4xi3D-2arzA:
undetectable		 4xi3D-2arzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 2arz HYPOTHETICAL PROTEIN
PA4388
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 153
LEU A  41
HIS A 201
CYH A  40
 None
 1.23A 5eu8A-2arzA:
2.5		 5eu8A-2arzA:
19.23