SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2as0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		6 / 12 PHE A 201
PHE A 225
TYR A 227
ALA A 252
ALA A 276
PRO A 298
 None
 1.03A 2igtA-2as0A:
22.5		 2igtA-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 PHE A 225
SER A 249
ALA A 252
ALA A 276
PRO A 298
 None
 0.64A 2igtA-2as0A:
22.5		 2igtA-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		6 / 12 PHE A 201
PHE A 225
TYR A 227
ALA A 252
ALA A 276
PRO A 298
 None
 0.99A 2igtB-2as0A:
22.4		 2igtB-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 PHE A 225
SER A 249
ALA A 252
ALA A 276
PRO A 298
 None
 0.60A 2igtB-2as0A:
22.4		 2igtB-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		6 / 12 PHE A 201
PHE A 225
TYR A 227
ALA A 252
ALA A 276
PRO A 298
 None
 1.01A 2igtC-2as0A:
22.2		 2igtC-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 PHE A 225
SER A 249
ALA A 252
ALA A 276
PRO A 298
 None
 0.63A 2igtC-2as0A:
22.2		 2igtC-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 ILE A 292
LEU A 222
ALA A 260
VAL A 265
ASP A 223
 None
 1.16A 2yvlB-2as0A:
17.1		 2yvlB-2as0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 ILE A 292
LEU A 222
ALA A 260
VAL A 265
ASP A 223
 None
 1.20A 2yvlC-2as0A:
16.4		 2yvlC-2as0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 ARG A 208
ASP A 247
SER A 249
ALA A 276
ASP A 296
 None
 0.59A 3axtA-2as0A:
20.0		 3axtA-2as0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		4 / 6 VAL A   6
VAL A  27
PHE A  22
ARG A  44
 None
 1.22A 3bjwF-2as0A:
undetectable		 3bjwF-2as0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 GLY A  50
ILE A  20
VAL A  21
 None
 0.50A 3nv6A-2as0A:
undetectable		 3nv6A-2as0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 GLY A 229
ILE A 244
VAL A 243
 None
 0.49A 3nv6A-2as0A:
undetectable		 3nv6A-2as0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 9 PHE A 225
TYR A 227
ASP A 247
SER A 249
PRO A 298
 None
 0.61A 3v8vA-2as0A:
26.9		 3v8vA-2as0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		6 / 12 ARG A 208
PHE A 225
TYR A 227
SER A 249
ASP A 296
PRO A 298
 None
 0.66A 3v8vB-2as0A:
22.3		 3v8vB-2as0A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		6 / 12 ARG A 208
TYR A 227
ASP A 247
ALA A 276
ASP A 296
PRO A 298
 None
 0.51A 4dmgA-2as0A:
45.8		 4dmgA-2as0A:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		6 / 11 ARG A 208
TYR A 227
ASP A 247
ALA A 276
ASP A 296
PRO A 298
 None
 0.61A 4dmgB-2as0A:
45.2		 4dmgB-2as0A:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		4 / 7 VAL A   4
VAL A  41
LEU A  49
ASN A  59
 None
 1.07A 4e1gB-2as0A:
undetectable		 4e1gB-2as0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 GLY A 229
GLY A 230
SER A 249
ASP A 296
PRO A 298
 None
 0.74A 4fp9A-2as0A:
14.3		 4fp9A-2as0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 GLY A 229
GLY A 230
SER A 249
ASP A 296
PRO A 298
 None
 0.74A 4fp9C-2as0A:
14.3		 4fp9C-2as0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 GLY A 229
GLY A 230
SER A 249
ASP A 296
PRO A 298
 None
 0.73A 4fp9F-2as0A:
14.4		 4fp9F-2as0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 10 LEU A 324
PHE A 290
VAL A 293
ILE A 244
ALA A 276
 None
 1.10A 4j14A-2as0A:
undetectable		 4j14A-2as0A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 11 ALA A 240
GLU A 212
GLY A 264
ASN A 263
GLU A 242
 None
 1.21A 4jdsD-2as0A:
0.0		 4jdsD-2as0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 ALA A 276
PHE A 225
GLY A 321
ALA A 320
ALA A 313
 None
 0.94A 4nkxB-2as0A:
undetectable		 4nkxB-2as0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		4 / 8 ILE A 141
ILE A  82
ASN A  86
ALA A  85
 None
 0.85A 4ou1A-2as0A:
1.6		 4ou1A-2as0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		4 / 8 LEU A 388
VAL A 294
LEU A 295
PHE A 300
 None
 0.90A 4r3aA-2as0A:
undetectable		 4r3aA-2as0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 11 PHE A 225
ASP A 247
SER A 275
ASP A 296
PRO A 298
 None
 0.49A 4rtrA-2as0A:
10.2		 4rtrA-2as0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 PHE A 225
ASP A 247
SER A 275
ASP A 296
PRO A 298
 None
 0.45A 4rtsA-2as0A:
11.3		 4rtsA-2as0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		4 / 5 GLU A 184
ILE A 182
PHE A 189
VAL A 191
 None
 1.25A 4tvtA-2as0A:
0.0		 4tvtA-2as0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 8 GLY A 245
VAL A 243
ALA A 235
LEU A 211
GLY A 230
 None
 1.24A 4zauA-2as0A:
undetectable		 4zauA-2as0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		5 / 12 PHE A 225
GLY A 230
ALA A 276
ASP A 296
PRO A 298
 None
 0.76A 5e72A-2as0A:
5.3		 5e72A-2as0A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 ALA A 320
ASN A 323
LEU A 324
 None
 0.48A 5i1nC-2as0A:
undetectable		 5i1nC-2as0A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 ALA A 320
ASN A 323
LEU A 324
 None
 0.51A 5i1oA-2as0A:
undetectable		 5i1oA-2as0A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 ALA A 320
ASN A 323
LEU A 324
 None
 0.39A 5i1pA-2as0A:
undetectable		 5i1pA-2as0A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 ALA A 320
ASN A 323
LEU A 324
 None
 0.50A 5i1pD-2as0A:
undetectable		 5i1pD-2as0A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		4 / 6 PRO A 110
GLY A  52
PHE A  78
ARG A  81
 None
 1.17A 5jcnB-2as0A:
3.0		 5jcnB-2as0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 ALA A 210
PHE A 231
GLN A 204
 None
 0.61A 6eceA-2as0A:
undetectable		 6eceA-2as0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2as0 HYPOTHETICAL PROTEIN
PH1915
(Pyrococcus
horikoshii) 		3 / 3 LYS A 358
VAL A 392
ASP A 394
 None
 0.51A 6fgdA-2as0A:
undetectable		 6fgdA-2as0A:
23.61