SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2as9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 1p7lD-2as9A:
undetectable		 1p7lD-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 1p7lC-2as9A:
undetectable		 1p7lC-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 ILE A  36
ILE A  79
THR A  34
 None
 0.58A 1rg7A-2as9A:
undetectable		 1rg7A-2as9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 1rg9B-2as9A:
undetectable		 1rg9B-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.66A 1rg9A-2as9A:
undetectable		 1rg9A-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 1rg9D-2as9A:
undetectable		 1rg9D-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 1rg9C-2as9A:
undetectable		 1rg9C-2as9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		5 / 11 ALA A 187
ILE A 142
ILE A 194
VAL A 169
VAL A 162
 None
 1.06A 2nnpB-2as9A:
undetectable		 2nnpB-2as9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 ILE A  36
PHE A 107
HIS A 201
 None
 0.72A 3h0aA-2as9A:
undetectable		 3h0aA-2as9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 VAL A 102
HIS A  54
VAL A  29
ILE A  35
 None
 0.89A 4jq1B-2as9A:
undetectable		 4jq1B-2as9A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.60A 4kttB-2as9A:
undetectable		 4kttB-2as9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.65A 4kttD-2as9A:
undetectable		 4kttD-2as9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.58A 4ndnB-2as9A:
undetectable		 4ndnB-2as9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.66A 4ndnD-2as9A:
undetectable		 4ndnD-2as9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 PHE A  14
THR A  26
LEU A 163
 None
 0.72A 4qztA-2as9A:
undetectable		 4qztA-2as9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 8 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.76A 5t8sA-2as9A:
undetectable		 5t8sA-2as9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 PHE A 197
ASP A 196
LYS A 200
 None
 0.77A 6awtD-2as9A:
undetectable		 6awtD-2as9A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2as9 SERINE PROTEASE
(Staphylococcus
aureus) 		4 / 7 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.70A 6fbnA-2as9A:
undetectable		 6fbnA-2as9A:
18.77