SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2asb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 144
SER A 142
VAL A 170
LEU A 181
 None
 1.17A 1yajB-2asbA:
undetectable		 1yajB-2asbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 168
CYH A 165
SER A 182
LEU A 181
THR A 180
 None
 1.19A 3a35A-2asbA:
2.5		 3a35A-2asbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 168
CYH A 165
LEU A 181
THR A 180
GLN A 151
 None
 1.18A 3a35B-2asbA:
2.4		 3a35B-2asbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 168
CYH A 165
SER A 182
LEU A 181
THR A 180
 None
 1.18A 3a35B-2asbA:
2.4		 3a35B-2asbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 168
CYH A 165
SER A 182
LEU A 181
THR A 180
 None
 1.14A 3a3bA-2asbA:
undetectable		 3a3bA-2asbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 162
GLY A 136
ALA A 116
GLY A 117
ILE A 179
 None
 1.18A 3ku1G-2asbA:
undetectable		 3ku1G-2asbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 303
LEU A 299
ASP A 322
VAL A 294
VAL A 277
 A  B   7 ( 3.6A)
A  B   7 ( 4.0A)
U  B   9 ( 3.8A)
None
None
 0.76A 3rukB-2asbA:
undetectable		 3rukB-2asbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 321
ASP A 322
ILE A 323
GLY A 304
 A  B  10 ( 4.6A)
U  B   9 ( 3.8A)
A  B   8 ( 3.9A)
C  B   6 ( 4.7A)
 0.84A 4ac9C-2asbA:
undetectable		 4ac9C-2asbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 321
ASP A 322
ILE A 323
GLY A 304
 A  B  10 ( 4.6A)
U  B   9 ( 3.8A)
A  B   8 ( 3.9A)
C  B   6 ( 4.7A)
 0.82A 4acaC-2asbA:
undetectable		 4acaC-2asbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 207
ILE A 255
SER A 218
LEU A 316
 None
 0.98A 4m51A-2asbA:
undetectable		 4m51A-2asbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
ILE A 236
GLY A 237
ILE A 207
VAL A 222
 None
G  B   1 ( 4.0A)
None
None
None
 0.97A 4nptA-2asbA:
undetectable		 4nptA-2asbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 195
LEU A 188
ILE A 207
VAL A 210
 None
 0.78A 4ojbA-2asbA:
undetectable		 4ojbA-2asbA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 290
VAL A 280
VAL A 294
ALA A 275
ALA A 310
 None
None
None
None
A  B   8 ( 3.6A)
 0.95A 6h1lB-2asbA:
undetectable		 6h1lB-2asbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 207
GLY A 228
ARG A 244
ALA A 234
 None
 0.83A 6hd6B-2asbA:
undetectable		 6hd6B-2asbA:
15.57