SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ass'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 SER B2291
ASP B2319
SER B2264
ASN B2289
 None
 1.09A 2cmlA-2assB:
undetectable		 2cmlA-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 SER B2318
ASP B2316
SER B2341
SER B2343
 None
 1.06A 2cmlA-2assB:
undetectable		 2cmlA-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER B2291
ASP B2319
SER B2264
ASN B2289
 None
 0.98A 2cmlB-2assB:
undetectable		 2cmlB-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER B2291
ASP B2319
SER B2264
ASN B2289
 None
 1.10A 2cmlC-2assB:
undetectable		 2cmlC-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER B2318
ASP B2316
SER B2341
SER B2343
 None
 1.06A 2cmlC-2assB:
undetectable		 2cmlC-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER B2291
ASP B2319
SER B2264
ASN B2289
 None
 1.10A 2cmlD-2assB:
undetectable		 2cmlD-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU B2156
LEU B2226
MET B2186
LEU B2198
PHE B2178
 None
 1.36A 2oaxE-2assB:
undetectable		 2oaxE-2assB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU B2288
ASN B2289
LEU B2261
VAL B2274
LEU B2297
 None
 1.38A 2q7kA-2assB:
undetectable		 2q7kA-2assB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER B2320
LEU B2340
LEU B2315
PHE B2331
THR B2394
 None
 1.21A 2v0mC-2assB:
undetectable		 2v0mC-2assB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 10 ARG B2217
THR B2270
ASN B2296
GLU B2271
LYS B2272
 None
 1.40A 2z71A-2assB:
0.0
2z71C-2assB:
0.0		 2z71A-2assB:
19.06
2z71C-2assB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 CYH B2165
SER B2168
LEU B2147
LEU B2156
LEU B2216
 None
 1.27A 3adsA-2assB:
undetectable		 3adsA-2assB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU B2100
VAL B2123
ARG B2126
 None
 0.78A 3b0wB-2assB:
undetectable		 3b0wB-2assB:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY B2239
CYH B2240
ILE B2222
LEU B2198
LEU B2235
 PO4  B   5 ( 4.4A)
None
None
None
None
 1.32A 3cs8A-2assB:
undetectable		 3cs8A-2assB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU B2251
VAL B2223
LEU B2263
ASP B2268
 None
 0.82A 3cs9D-2assB:
undetectable		 3cs9D-2assB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 8 LEU B2235
LEU B2263
ILE B2285
VAL B2281
LEU B2252
 None
 0.92A 3kp6A-2assB:
undetectable
3kp6B-2assB:
undetectable		 3kp6A-2assB:
16.67
3kp6B-2assB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 4 ASN B2224
SER B2212
LEU B2213
THR B2250
 None
 1.28A 4an2A-2assB:
undetectable		 4an2A-2assB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU B2356
LEU B2362
ILE B2348
ILE B2370
LEU B2379
 None
 1.22A 4j24B-2assB:
undetectable		 4j24B-2assB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 10 ASP B2187
LEU B2216
LEU B2198
ILE B2201
LEU B2202
 None
 0.89A 4odoA-2assB:
undetectable		 4odoA-2assB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 10 ASP B2187
LEU B2216
LEU B2198
ILE B2201
LEU B2202
 None
 0.95A 4odoC-2assB:
undetectable		 4odoC-2assB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP B2187
LEU B2216
LEU B2198
ILE B2201
LEU B2202
 None
 0.93A 4odrA-2assB:
undetectable
4odrB-2assB:
undetectable		 4odrA-2assB:
14.80
4odrB-2assB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU B2235
VAL B2183
LEU B2213
CYH B2205
LEU B2202
 None
 1.11A 4p65B-2assB:
undetectable
4p65D-2assB:
undetectable
4p65G-2assB:
undetectable
4p65H-2assB:
undetectable		 4p65B-2assB:
7.37
4p65D-2assB:
7.37
4p65G-2assB:
7.11
4p65H-2assB:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 PHE B2181
ILE B2201
ASP B2187
 None
 0.63A 5cswA-2assB:
undetectable		 5cswA-2assB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 PHE B2181
ILE B2201
ASP B2187
 None
 0.54A 5cswB-2assB:
undetectable		 5cswB-2assB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY B2215
CYH B2240
GLY B2239
SER B2264
 PO4  B   5 (-3.6A)
None
PO4  B   5 ( 4.4A)
None
 0.50A 5vw9A-2assB:
undetectable		 5vw9A-2assB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU B2218
GLY B2200
GLN B2204
ILE B2193
MET B2186
 None
 1.24A 5y2tA-2assB:
undetectable		 5y2tA-2assB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 9 LEU B2198
VAL B2192
SER B2191
ASP B2171
 None
 0.98A 6c2mD-2assB:
undetectable		 6c2mD-2assB:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 THR B2270
CYH B2266
TYR B2293
LEU B2248
 None
 1.40A 6cnjD-2assB:
undetectable
6cnjE-2assB:
undetectable		 6cnjD-2assB:
11.31
6cnjE-2assB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU B2248
ASN B2289
LEU B2258
 None
 0.70A 6exiA-2assB:
undetectable		 6exiA-2assB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU B2305
ASN B2262
LEU B2252
 None
 0.59A 6exiA-2assB:
undetectable		 6exiA-2assB:
12.03