SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ast'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		5 / 11 ASP A1111
ASN A1108
CYH A1120
THR A1119
GLY A1114
 None
 1.31A 1jr1A-2astA:
undetectable		 1jr1A-2astA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		4 / 8 ASP A1111
ASN A1108
THR A1119
GLY A1114
 None
 0.84A 1jr1B-2astA:
undetectable		 1jr1B-2astA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		4 / 7 LEU A1115
VAL A1118
THR A1119
VAL A1095
 None
 0.72A 2qblA-2astA:
undetectable		 2qblA-2astA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1
(Homo
sapiens) 		5 / 8 VAL C3022
LEU C3067
ILE C3006
VAL C3048
LEU C3046
 None
 1.24A 3kp6A-2astC:
undetectable
3kp6B-2astC:
undetectable		 3kp6A-2astC:
16.56
3kp6B-2astC:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		5 / 11 LEU A1103
ALA A1106
LEU A1110
GLY A1114
LEU A1116
 None
 1.25A 3uudA-2astA:
undetectable		 3uudA-2astA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		5 / 8 ASP A1111
ASN A1108
CYH A1120
THR A1119
GLY A1114
 None
 1.46A 4fo4A-2astA:
undetectable		 4fo4A-2astA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1
(Homo
sapiens) 		3 / 3 MET C3038
GLU C3042
LEU C3046
 None
 0.76A 4v2oB-2astC:
undetectable		 4v2oB-2astC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		5 / 9 LEU A1116
GLY A1114
LEU A1115
LEU A1103
ALA A1107
 None
 1.05A 5dqfA-2astA:
undetectable		 5dqfA-2astA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A
(Homo
sapiens) 		5 / 10 LEU A1103
ALA A1106
LEU A1110
GLY A1114
LEU A1116
 None
 1.27A 5dxbA-2astA:
undetectable		 5dxbA-2astA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1
(Homo
sapiens) 		3 / 3 SER C3009
TYR C3008
TYR C3007
 None
 0.74A 5lakA-2astC:
undetectable
5lakI-2astC:
undetectable		 5lakA-2astC:
11.80
5lakI-2astC:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1
(Homo
sapiens) 		3 / 3 SER C3009
TYR C3008
TYR C3007
 None
 0.73A 5lakC-2astC:
undetectable
5lakJ-2astC:
undetectable		 5lakC-2astC:
11.80
5lakJ-2astC:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG C3071
ARG C3044
ARG C3020
 None
 0.96A 6bplA-2astC:
undetectable
6bplB-2astC:
undetectable		 6bplA-2astC:
15.00
6bplB-2astC:
15.00