SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2asu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 ARG B 696
THR B 600
VAL B 596
 None
 0.93A 1hxbA-2asuB:
1.0		 1hxbA-2asuB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 663
LEU B 498
ILE B 517
ILE B 587
LEU B 511
 None
 1.12A 1kyvA-2asuB:
undetectable
1kyvE-2asuB:
undetectable		 1kyvA-2asuB:
23.24
1kyvE-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 587
LEU B 511
GLY B 663
LEU B 498
ILE B 517
 None
 1.15A 1kyvB-2asuB:
undetectable
1kyvC-2asuB:
undetectable		 1kyvB-2asuB:
23.24
1kyvC-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 587
LEU B 511
GLY B 663
LEU B 498
ILE B 517
 None
 1.15A 1kyvC-2asuB:
undetectable
1kyvD-2asuB:
undetectable		 1kyvC-2asuB:
23.24
1kyvD-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 587
LEU B 511
GLY B 663
LEU B 498
ILE B 517
 None
 1.15A 1kyvD-2asuB:
undetectable
1kyvE-2asuB:
undetectable		 1kyvD-2asuB:
23.24
1kyvE-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 587
LEU B 511
ALA B 666
GLY B 663
LEU B 498
 None
 0.92A 2a58A-2asuB:
undetectable
2a58B-2asuB:
undetectable		 2a58A-2asuB:
23.24
2a58B-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 587
LEU B 511
ALA B 666
GLY B 663
LEU B 498
 None
 0.91A 2a58B-2asuB:
undetectable
2a58C-2asuB:
undetectable		 2a58B-2asuB:
23.24
2a58C-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 587
LEU B 511
ALA B 666
GLY B 663
LEU B 498
 None
 0.92A 2a58D-2asuB:
undetectable
2a58E-2asuB:
undetectable		 2a58D-2asuB:
23.24
2a58E-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 ARG B 696
THR B 600
VAL B 596
 None
 0.87A 2qakA-2asuB:
0.0		 2qakA-2asuB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 506
PHE B 524
ILE B 517
GLY B 533
 None
 0.91A 2v0mC-2asuB:
undetectable		 2v0mC-2asuB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 THR B 495
SER B 510
GLU B 603
ALA B 666
 None
 0.97A 2v32A-2asuB:
undetectable
2v32B-2asuB:
undetectable		 2v32A-2asuB:
18.11
2v32B-2asuB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 THR B 495
SER B 510
GLU B 603
ALA B 666
 None
 0.95A 2v32A-2asuB:
undetectable
2v32B-2asuB:
undetectable		 2v32A-2asuB:
18.11
2v32B-2asuB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 GLY B 509
ILE B 678
ALA B 520
PHE B 694
 None
 0.86A 3aodA-2asuB:
undetectable		 3aodA-2asuB:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 GLY B 663
GLY B 659
GLY B 508
 None
 0.38A 3bogC-2asuB:
undetectable		 3bogC-2asuB:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.96A 3embA-2asuB:
undetectable		 3embA-2asuB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 GLY B 663
GLY B 662
SER B 510
LEU B 569
 None
 0.75A 3o9mB-2asuB:
undetectable		 3o9mB-2asuB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 LEU B 665
GLY B 677
LEU B 675
GLU B 676
 None
 1.08A 3tgvB-2asuB:
3.1		 3tgvB-2asuB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 ALA B 666
TRP B 673
VAL B 674
 None
 0.26A 4w9nC-2asuB:
undetectable		 4w9nC-2asuB:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.88A 5e9qA-2asuB:
undetectable		 5e9qA-2asuB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.84A 5ec8A-2asuB:
undetectable		 5ec8A-2asuB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.87A 5ehgA-2asuB:
undetectable		 5ehgA-2asuB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.89A 5ehiA-2asuB:
undetectable		 5ehiA-2asuB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 1.03A 5ehiC-2asuB:
undetectable		 5ehiC-2asuB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.87A 5eiwA-2asuB:
undetectable		 5eiwA-2asuB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.88A 5ekxA-2asuB:
undetectable		 5ekxA-2asuB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 TYR B 594
LEU B 665
THR B 600
GLY B 677
VAL B 697
 None
 1.17A 5jo9A-2asuB:
undetectable		 5jo9A-2asuB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 HIS B 488
ASN B 620
ALA B 605
 None
 0.80A 5n4tB-2asuB:
undetectable		 5n4tB-2asuB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.96A 5vimA-2asuB:
undetectable		 5vimA-2asuB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.94A 5vimB-2asuB:
undetectable		 5vimB-2asuB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.91A 5wz2C-2asuB:
undetectable		 5wz2C-2asuB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 PRO B 598
GLY B 599
THR B 600
ASN B 625
 None
 1.01A 5xxiA-2asuB:
undetectable		 5xxiA-2asuB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 498
GLY B 508
HIS B 505
SER B 567
ILE B 680
 None
 1.33A 6bxnB-2asuB:
undetectable		 6bxnB-2asuB:
21.82