SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2atc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		5 / 10 LEU A  30
ALA A 293
LEU A 297
LEU A 303
LEU A  24
 None
 1.26A 1gwrA-2atcA:
undetectable		 1gwrA-2atcA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 ARG A 264
THR A 275
VAL A 272
 None
 0.76A 1hxbA-2atcA:
undetectable		 1hxbA-2atcA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 ARG A 113
ASP A  19
ASN A  21
 None
 0.84A 1nbhA-2atcA:
4.6		 1nbhA-2atcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 ARG A 113
ASP A  19
ASN A  21
 None
 0.84A 1nbhD-2atcA:
3.3		 1nbhD-2atcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		4 / 5 ASP A 141
LEU A  24
ALA A 175
LEU A 172
 None
 0.82A 1nh8A-2atcA:
undetectable		 1nh8A-2atcA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		4 / 5 ALA A 127
PHE A  59
ASN A 126
ILE A   9
 None
 1.07A 1yc2D-2atcA:
4.3		 1yc2D-2atcA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 LYS A  31
ASP A 141
ASN A 286
 None
 1.14A 2bm9A-2atcA:
5.4		 2bm9A-2atcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 ARG A 264
THR A 275
VAL A 272
 None
 0.87A 2qakA-2atcA:
undetectable		 2qakA-2atcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
, REGULATORY CHAIN
(Escherichia
coli;
Escherichia
coli) 		4 / 7 ILE B 115
LEU A 114
ARG A 105
MET A 104
 None
 1.02A 3ag2N-2atcB:
undetectable
3ag2W-2atcB:
undetectable		 3ag2N-2atcB:
13.32
3ag2W-2atcB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
, REGULATORY CHAIN
(Escherichia
coli;
Escherichia
coli) 		4 / 6 ILE B 115
LEU A 114
ARG A 105
MET A 104
 None
 1.04A 3wg7A-2atcB:
undetectable
3wg7J-2atcB:
undetectable		 3wg7A-2atcB:
13.32
3wg7J-2atcB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 PHE A 184
THR A 148
LEU A 172
 None
 0.76A 4qztA-2atcA:
undetectable		 4qztA-2atcA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 ARG A 183
GLU A 217
TYR A 185
 None
 0.95A 4r29D-2atcA:
undetectable		 4r29D-2atcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		5 / 11 LEU A  30
ALA A 293
LEU A 297
LEU A 303
LEU A  24
 None
 1.26A 5dxgB-2atcA:
undetectable		 5dxgB-2atcA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		3 / 3 ASN A 244
SER A 213
SER A 214
 None
 0.73A 5gsnA-2atcA:
2.9		 5gsnA-2atcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		5 / 11 LEU A  30
ALA A 293
LEU A 297
LEU A 303
LEU A  24
 None
 1.26A 5hyrB-2atcA:
undetectable		 5hyrB-2atcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		5 / 9 LEU A 259
HIS A 260
PRO A 261
VAL A 169
LEU A 172
 None
 1.48A 5o96E-2atcA:
3.8
5o96F-2atcA:
undetectable		 5o96E-2atcA:
23.19
5o96F-2atcA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		4 / 6 LEU A  30
GLN A 292
LEU A  39
LEU A  38
 None
 1.19A 5yvnA-2atcA:
undetectable		 5yvnA-2atcA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		4 / 8 TRP A 279
ARG A 264
HIS A 260
ASP A 273
 None
 1.17A 6mn4A-2atcA:
2.4		 6mn4A-2atcA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
(Escherichia
coli) 		4 / 8 ASP A 228
HIS A 134
ARG A 226
ASP A 141
 None
 1.18A 6mn4D-2atcA:
2.3		 6mn4D-2atcA:
23.60