SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2atf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		3 / 3 SER A 146
GLU A  79
GLU A 149
 None
 0.71A 1eqbD-2atfA:
undetectable		 1eqbD-2atfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		3 / 3 SER A 146
GLU A  79
GLU A 149
 None
 0.71A 1eqbB-2atfA:
undetectable		 1eqbB-2atfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		4 / 4 ILE A  18
ASP A  64
LEU A 154
ARG A  10
 None
 1.44A 2a7qA-2atfA:
undetectable		 2a7qA-2atfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		4 / 5 LEU A  75
HIS A 140
HIS A  88
HIS A  86
 None
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 0.94A 3kecA-2atfA:
undetectable		 3kecA-2atfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.14A 3mekA-2atfA:
0.5		 3mekA-2atfA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.14A 3qwpA-2atfA:
undetectable		 3qwpA-2atfA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 10 GLU A 127
ASN A 128
TYR A  40
ALA A  45
GLU A  46
 None
 1.43A 3u6tA-2atfA:
undetectable		 3u6tA-2atfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		4 / 5 HIS A 140
LEU A 154
TRP A  77
LEU A 156
 NI  A 201 (-3.3A)
None
None
None
 1.31A 4aqlA-2atfA:
undetectable		 4aqlA-2atfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		4 / 5 LEU A  98
GLU A  46
LEU A  37
HIS A 155
 None
 1.25A 4xi3B-2atfA:
undetectable		 4xi3B-2atfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		3 / 3 LYS A 184
ARG A 188
HIS A 182
 None
 1.09A 4zbrA-2atfA:
undetectable		 4zbrA-2atfA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.15A 5cclA-2atfA:
undetectable		 5cclA-2atfA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.14A 5ccmA-2atfA:
undetectable		 5ccmA-2atfA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.17A 5v37A-2atfA:
undetectable		 5v37A-2atfA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.15A 5xxgA-2atfA:
undetectable		 5xxgA-2atfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.15A 5xxjA-2atfA:
undetectable		 5xxjA-2atfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		5 / 12 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.15A 5yjoA-2atfA:
undetectable		 5yjoA-2atfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2atf CYSTEINE DIOXYGENASE
TYPE I
(Mus
musculus) 		3 / 3 VAL A 152
ALA A  51
GLN A  99
 None
 0.67A 6gb9A-2atfA:
undetectable		 6gb9A-2atfA:
16.16