SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2atv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		4 / 6 VAL A  81
ILE A 156
ILE A 114
LEU A 115
 None
 0.76A 3hegA-2atvA:
undetectable		 3hegA-2atvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		3 / 3 GLU A  40
LEU A  59
LEU A  22
 None
 0.77A 3ohtA-2atvA:
undetectable		 3ohtA-2atvA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		3 / 3 LEU A  98
ASP A 103
ILE A  11
 None
 0.50A 4xi3D-2atvA:
undetectable		 4xi3D-2atvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		4 / 7 ALA A 149
ARG A  14
GLY A  13
GLU A  94
 GDP  A 415 (-3.7A)
None
None
None
 0.88A 5bs8A-2atvA:
undetectable
5bs8C-2atvA:
undetectable
5bs8D-2atvA:
3.7		 5bs8A-2atvA:
17.43
5bs8C-2atvA:
17.43
5bs8D-2atvA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		4 / 6 ALA A 149
ARG A  14
GLY A  13
GLU A  94
 GDP  A 415 (-3.7A)
None
None
None
 0.88A 5btgA-2atvA:
undetectable
5btgB-2atvA:
4.0
5btgC-2atvA:
undetectable		 5btgA-2atvA:
17.43
5btgB-2atvA:
24.06
5btgC-2atvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		4 / 4 LEU A 115
ILE A 114
GLY A 117
ILE A 159
 None
 0.87A 5dzk3-2atvA:
undetectable
5dzkm-2atvA:
undetectable		 5dzk3-2atvA:
2.47
5dzkm-2atvA:
21.92