SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2atx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		4 / 6 ASP A  90
VAL A  21
GLY A  68
TYR A  70
 None
 1.29A 1ekjC-2atxA:
3.5
1ekjD-2atxA:
3.6		 1ekjC-2atxA:
22.67
1ekjD-2atxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1jnoA-2atxA:
undetectable		 1jnoA-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1jnoB-2atxA:
undetectable		 1jnoB-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.91A 1magA-2atxA:
undetectable		 1magA-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.91A 1magB-2atxA:
undetectable		 1magB-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1ng8A-2atxA:
undetectable		 1ng8A-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1ng8B-2atxA:
undetectable		 1ng8B-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.90A 1nruA-2atxA:
undetectable		 1nruA-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.90A 1nruB-2atxA:
undetectable		 1nruB-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		5 / 11 VAL A 107
GLY A  24
ALA A 119
TYR A  86
PHE A 124
 None
 1.49A 3qxyB-2atxA:
undetectable
3qxyQ-2atxA:
undetectable		 3qxyB-2atxA:
17.48
3qxyQ-2atxA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		4 / 8 LEU A 125
VAL A 112
LEU A 115
ILE A  94
 None
 0.87A 4r38D-2atxA:
undetectable		 4r38D-2atxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		4 / 7 THR A  31
LEU A  34
VAL A  56
TYR A  54
 MG  A 201 ( 3.3A)
None
None
None
 1.11A 5ov9A-2atxA:
undetectable		 5ov9A-2atxA:
16.31