SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2au1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 268
ALA A 269
ASP A 270
VAL A 298
ILE A 239
 None
 0.85A 1hshA-2au1A:
undetectable		 1hshA-2au1A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		6 / 12 LEU A 249
GLY A 268
ALA A 269
ASP A 270
VAL A 298
ILE A 239
 None
 1.31A 2rkgA-2au1A:
undetectable		 2rkgA-2au1A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 268
ALA A 269
ASP A 270
VAL A 298
ILE A 239
 None
 0.73A 2rkgB-2au1A:
undetectable		 2rkgB-2au1A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 8 GLY A 268
ALA A 269
ASP A 270
ILE A 239
 None
 0.53A 3el0A-2au1A:
undetectable		 3el0A-2au1A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		3 / 3 SER A 287
ASP A  81
ASN A 101
 None
 1.00A 3lsfB-2au1A:
undetectable
3lsfE-2au1A:
undetectable		 3lsfB-2au1A:
21.26
3lsfE-2au1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		3 / 3 ASP A  81
ASN A 101
SER A 287
 None
 1.02A 3lsfB-2au1A:
undetectable
3lsfE-2au1A:
undetectable		 3lsfB-2au1A:
21.26
3lsfE-2au1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		3 / 3 ASP A  81
ASN A 101
SER A 287
 None
 0.83A 3lslA-2au1A:
undetectable
3lslD-2au1A:
undetectable		 3lslA-2au1A:
21.29
3lslD-2au1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		3 / 3 SER A 287
ASP A  81
ASN A 101
 None
 0.90A 3lslA-2au1A:
undetectable
3lslD-2au1A:
undetectable		 3lslA-2au1A:
21.29
3lslD-2au1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 207
PHE A 180
ILE A 181
ILE A 114
HIS A 104
 None
 1.01A 3o1cA-2au1A:
undetectable		 3o1cA-2au1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 207
PHE A 180
ILE A 181
ILE A 114
HIS A 104
 None
 0.99A 3o1xA-2au1A:
undetectable		 3o1xA-2au1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 ALA A  97
GLY A 100
MET A 102
ASP A 284
PHE A 161
 None
 1.34A 3pfgA-2au1A:
undetectable		 3pfgA-2au1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 207
PHE A 180
ILE A 181
ILE A 114
HIS A 104
 None
 0.98A 3qgzA-2au1A:
undetectable		 3qgzA-2au1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 268
ALA A 269
ASP A 270
VAL A 298
ILE A 239
 None
 0.78A 3s54B-2au1A:
undetectable		 3s54B-2au1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 8 ILE A 181
ASP A 178
ILE A 177
SER A 150
GLY A 100
 None
 1.37A 4ac9C-2au1A:
undetectable		 4ac9C-2au1A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 4 ASP A  90
LEU A  93
ARG A 259
THR A  85
 None
None
BME  A 400 (-3.6A)
None
 1.43A 4kjjA-2au1A:
undetectable		 4kjjA-2au1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 4 ASP A  90
LEU A  93
ARG A 259
THR A  85
 None
None
BME  A 400 (-3.6A)
None
 1.35A 4kjkA-2au1A:
undetectable		 4kjkA-2au1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 5 ASP A  90
LEU A  93
ARG A 259
THR A  85
 None
None
BME  A 400 (-3.6A)
None
 1.41A 4p3qA-2au1A:
undetectable		 4p3qA-2au1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  95
VAL A 171
MET A 179
LEU A 103
LEU A 186
 None
 1.30A 4yb6A-2au1A:
undetectable
4yb6E-2au1A:
undetectable		 4yb6A-2au1A:
21.81
4yb6E-2au1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  95
VAL A 171
MET A 179
LEU A 103
LEU A 186
 None
 1.28A 4yb6B-2au1A:
undetectable
4yb6C-2au1A:
undetectable		 4yb6B-2au1A:
21.81
4yb6C-2au1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  95
VAL A 171
MET A 179
LEU A 103
LEU A 186
 None
 1.28A 4yb6C-2au1A:
undetectable
4yb6F-2au1A:
undetectable		 4yb6C-2au1A:
21.81
4yb6F-2au1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 MET A 179
LEU A 103
LEU A 186
GLY A  95
VAL A 171
 None
 1.27A 4yb6A-2au1A:
undetectable
4yb6D-2au1A:
undetectable		 4yb6A-2au1A:
21.81
4yb6D-2au1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 MET A 179
LEU A 103
LEU A 186
GLY A  95
VAL A 171
 None
 1.29A 4yb6D-2au1A:
undetectable
4yb6E-2au1A:
undetectable		 4yb6D-2au1A:
21.81
4yb6E-2au1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 10 MET A 179
LEU A 103
LEU A 186
GLY A  95
VAL A 171
 None
 1.30A 4yb6B-2au1A:
undetectable
4yb6F-2au1A:
undetectable		 4yb6B-2au1A:
21.81
4yb6F-2au1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 5 PHE A 326
HIS A 253
LEU A 323
PRO A 173
 None
 1.42A 5csyB-2au1A:
undetectable		 5csyB-2au1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 268
ALA A 269
ASP A 270
VAL A 298
ILE A 239
 None
 0.82A 5e5jA-2au1A:
undetectable		 5e5jA-2au1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 GLU A 154
ALA A  97
ALA A  96
VAL A 171
THR A  85
 None
 1.10A 5igjA-2au1A:
undetectable		 5igjA-2au1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 7 PHE A 326
ASP A 174
PHE A 172
GLY A 192
 None
 1.04A 5n9xA-2au1A:
undetectable		 5n9xA-2au1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		3 / 3 VAL A 298
LYS A 294
MET A 293
 None
 1.06A 5nknA-2au1A:
undetectable		 5nknA-2au1A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		4 / 4 ASN A 301
SER A 309
ALA A 307
VAL A 306
 None
 1.35A 5nm5A-2au1A:
undetectable		 5nm5A-2au1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 268
ALA A 269
ASP A 270
VAL A 298
ILE A 239
 None
 0.88A 5t8hA-2au1A:
undetectable		 5t8hA-2au1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2au1 IGG-DEGRADING
PROTEASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 323
GLY A 324
SER A 285
LEU A  93
ASP A 174
 None
 1.00A 6bxmA-2au1A:
undetectable		 6bxmA-2au1A:
23.17