SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2au3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 6 CYH A  59
VAL A  61
HIS A  38
CYH A  35
 ZN  A 501 (-2.3A)
None
ZN  A 501 (-3.0A)
ZN  A 501 (-2.2A)
 1.33A 1ekjG-2au3A:
3.8
1ekjH-2au3A:
3.7		 1ekjG-2au3A:
22.50
1ekjH-2au3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.82A 1p7lD-2au3A:
undetectable		 1p7lD-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.83A 1p7lC-2au3A:
undetectable		 1p7lC-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.81A 1rg9B-2au3A:
undetectable		 1rg9B-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.81A 1rg9A-2au3A:
undetectable		 1rg9A-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.82A 1rg9D-2au3A:
undetectable		 1rg9D-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.84A 1rg9C-2au3A:
undetectable		 1rg9C-2au3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 ASN A 276
LEU A 308
ALA A 312
SER A 311
 None
 1.03A 3kp6A-2au3A:
undetectable		 3kp6A-2au3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 7 ILE A 189
VAL A 187
ARG A 204
TYR A 127
 None
 0.75A 3p6hA-2au3A:
undetectable		 3p6hA-2au3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 7 ASP A 253
TYR A 251
GLU A 249
ARG A 204
 None
 1.19A 3s3oA-2au3A:
undetectable		 3s3oA-2au3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 7 ASP A 293
TYR A 251
GLU A 249
ARG A 204
 None
 1.16A 3s3oA-2au3A:
undetectable		 3s3oA-2au3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		5 / 12 LEU A 257
ASN A 264
GLU A 249
ALA A 278
LEU A 309
 None
 1.16A 3vywA-2au3A:
undetectable		 3vywA-2au3A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.91A 3w9tA-2au3A:
undetectable		 3w9tA-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.90A 3w9tB-2au3A:
undetectable		 3w9tB-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.91A 3w9tC-2au3A:
undetectable		 3w9tC-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.90A 3w9tD-2au3A:
undetectable		 3w9tD-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.91A 3w9tE-2au3A:
undetectable		 3w9tE-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.91A 3w9tF-2au3A:
undetectable		 3w9tF-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASP A 112
VAL A  61
GLY A  62
ASP A 108
 None
 0.90A 3w9tG-2au3A:
undetectable		 3w9tG-2au3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		3 / 3 ARG A 369
ARG A 366
ILE A 398
 None
 0.94A 4b7qA-2au3A:
undetectable		 4b7qA-2au3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		3 / 3 ARG A 369
ARG A 366
ILE A 398
 None
 0.92A 4b7qC-2au3A:
undetectable		 4b7qC-2au3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLY A 202
GLY A 200
LEU A 107
VAL A 110
 None
 0.70A 4fgzA-2au3A:
undetectable		 4fgzA-2au3A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLY A 202
GLY A 200
LEU A 107
VAL A 110
 None
 0.71A 4fgzB-2au3A:
undetectable		 4fgzB-2au3A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		3 / 3 LEU A 321
PRO A 322
ARG A 256
 None
 0.73A 4klrB-2au3A:
5.2		 4klrB-2au3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.86A 4kttD-2au3A:
undetectable		 4kttD-2au3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 5 ASN A 159
LEU A 161
LEU A 107
ASN A 170
 None
 1.24A 4n09C-2au3A:
undetectable		 4n09C-2au3A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		3 / 3 ALA A 245
GLN A 277
GLY A 226
 None
 0.61A 4odoC-2au3A:
undetectable		 4odoC-2au3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 7 GLU A 158
LYS A 157
LEU A 156
LEU A 171
 None
 0.81A 4wg0B-2au3A:
undetectable
4wg0C-2au3A:
undetectable		 4wg0B-2au3A:
2.46
4wg0C-2au3A:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		5 / 11 LEU A 152
GLU A 158
LYS A 157
LEU A 156
LEU A 171
 None
 0.90A 4wg0C-2au3A:
undetectable
4wg0D-2au3A:
undetectable
4wg0E-2au3A:
undetectable		 4wg0C-2au3A:
2.46
4wg0D-2au3A:
2.46
4wg0E-2au3A:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		5 / 11 LEU A 152
GLU A 158
LYS A 157
LEU A 156
LEU A 171
 None
 0.91A 4wg0E-2au3A:
undetectable
4wg0F-2au3A:
undetectable
4wg0G-2au3A:
undetectable		 4wg0E-2au3A:
2.46
4wg0F-2au3A:
2.46
4wg0G-2au3A:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 6 LEU A 229
ALA A 278
LEU A 280
VAL A 314
 None
 1.27A 5a6iA-2au3A:
undetectable		 5a6iA-2au3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 7 VAL A 266
ILE A 239
VAL A 288
ALA A 245
 None
 0.67A 5ospA-2au3A:
undetectable		 5ospA-2au3A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 8 GLN A  52
ASP A  64
ILE A  14
ILE A  18
 None
 0.91A 5t8sA-2au3A:
undetectable		 5t8sA-2au3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2au3 DNA PRIMASE
(Aquifex
aeolicus) 		4 / 7 VAL A 110
VAL A 188
PRO A 190
GLY A 200
 None
 0.91A 5x80C-2au3A:
undetectable
5x80D-2au3A:
undetectable		 5x80C-2au3A:
17.57
5x80D-2au3A:
17.57