SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2auj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		4 / 7 VAL D 300
VAL D 259
ARG D 224
LEU D 261
 None
 0.91A 1iepB-2aujD:
undetectable		 1iepB-2aujD:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		4 / 6 PRO D 349
MET D 351
ALA D 370
GLU D 375
 None
 1.12A 1qhyA-2aujD:
undetectable		 1qhyA-2aujD:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		4 / 6 PHE D 251
ALA D 305
LEU D 304
ILE D 270
 None
 1.00A 1sbrA-2aujD:
undetectable
1sbrB-2aujD:
undetectable		 1sbrA-2aujD:
20.97
1sbrB-2aujD:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		4 / 7 VAL D 347
ARG D 209
LEU D 387
PHE D 207
 None
 1.09A 2f78A-2aujD:
undetectable		 2f78A-2aujD:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		4 / 7 VAL D 347
ARG D 209
LEU D 387
PHE D 207
 None
 1.15A 2f78B-2aujD:
undetectable		 2f78B-2aujD:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		4 / 6 VAL D 347
ARG D 209
LEU D 387
PHE D 207
 None
 1.12A 2f8dA-2aujD:
undetectable		 2f8dA-2aujD:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		5 / 11 ALA D 369
GLU D 376
VAL D 355
ILE D 378
VAL D 361
 None
 1.06A 2uxpB-2aujD:
undetectable		 2uxpB-2aujD:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		3 / 3 ARG D 445
GLU D 436
SER D 197
 None
 0.90A 2xctD-2aujD:
undetectable		 2xctD-2aujD:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		5 / 8 ALA D 379
TYR D 345
TYR D 215
ILE D 367
HIS D 386
 None
 1.45A 2zm8A-2aujD:
undetectable		 2zm8A-2aujD:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		5 / 8 HIS D 332
LEU D 223
LEU D 242
VAL D 322
LEU D 335
 None
 1.29A 3kp6A-2aujD:
undetectable
3kp6B-2aujD:
undetectable		 3kp6A-2aujD:
17.68
3kp6B-2aujD:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		5 / 12 TYR D 205
VAL D 185
GLY D 201
SER D 197
LEU D 191
 None
 1.18A 4ot2A-2aujD:
undetectable		 4ot2A-2aujD:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Thermus
aquaticus) 		5 / 11 LEU D 313
LEU D 242
GLU D 338
ALA D 221
LEU D 335
 None
 0.97A 4wg0H-2aujD:
undetectable
4wg0I-2aujD:
undetectable
4wg0J-2aujD:
undetectable		 4wg0H-2aujD:
6.03
4wg0I-2aujD:
6.03
4wg0J-2aujD:
6.03