SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2auk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Escherichia
coli) 		4 / 8 THR A  85
GLN A 169
ILE A 167
ASP A  82
 None
 1.07A 2xytH-2aukA:
undetectable		 2xytH-2aukA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Escherichia
coli) 		4 / 7 THR A  85
GLN A 169
ILE A 167
ASP A  82
 None
 1.07A 2xytI-2aukA:
undetectable		 2xytI-2aukA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Escherichia
coli) 		4 / 4 ASP A 180
THR A  90
VAL A 174
SER A  93
 None
 1.27A 3wxoA-2aukA:
0.0		 3wxoA-2aukA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Escherichia
coli) 		5 / 12 LEU A  45
ASP A  68
GLY A  69
ALA A  73
VAL A  78
 None
 1.40A 5kbwB-2aukA:
undetectable		 5kbwB-2aukA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Escherichia
coli) 		3 / 3 THR A 108
PRO A 186
ARG A 184
 None
 0.68A 5nd7B-2aukA:
undetectable		 5nd7B-2aukA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN
(Escherichia
coli) 		5 / 12 LEU A 170
VAL A  96
GLY A  94
SER A  93
VAL A  88
 None
 1.45A 6a94A-2aukA:
undetectable		 6a94A-2aukA:
20.74