SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2av4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HVY_C_D16C416_1 (THYMIDYLATE SYNTHASE)	2av4	THIOREDOXIN-LIKE PROTEIN 4A (DIM1) (Plasmodium yoelii)	5 / 11	PHE A 87 ILE A 46 ASP A 51 GLY A 49 PHE A 48	None	1.40A	1hvyC-2av4A: undetectable	1hvyC-2av4A: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_A_SAMA801_1 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	2av4	THIOREDOXIN-LIKE PROTEIN 4A (DIM1) (Plasmodium yoelii)	4 / 6	ASP A 53 ASP A 95 ASN A 121 GLU A 61	None	1.29A	1rjdA-2av4A: undetectable	1rjdA-2av4A: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_B_SAMB802_1 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	2av4	THIOREDOXIN-LIKE PROTEIN 4A (DIM1) (Plasmodium yoelii)	4 / 6	ASP A 53 ASP A 95 ASN A 121 GLU A 61	None	1.29A	1rjdB-2av4A: undetectable	1rjdB-2av4A: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_C_SAMC803_1 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	2av4	THIOREDOXIN-LIKE PROTEIN 4A (DIM1) (Plasmodium yoelii)	4 / 6	ASP A 53 ASP A 95 ASN A 121 GLU A 61	None	1.30A	1rjdC-2av4A: undetectable	1rjdC-2av4A: 20.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HVY_C_D16C416_1","THYMIDYLATE SYNTHASE","2av4","THIOREDOXIN-LIKE PROTEIN 4A (DIM1)","Plasmodium yoelii",5,"PHE A  87;ILE A  46;ASP A  51;GLY A  49;PHE A  48","None","1.40A","1hvyC-2av4A:undetectable","1hvyC-2av4A:18.60"],["1RJD_A_SAMA801_1","CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT","2av4","THIOREDOXIN-LIKE PROTEIN 4A (DIM1)","Plasmodium yoelii",4,"ASP A  53;ASP A  95;ASN A 121;GLU A  61","None","1.29A","1rjdA-2av4A:undetectable","1rjdA-2av4A:20.30"],["1RJD_B_SAMB802_1","CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT","2av4","THIOREDOXIN-LIKE PROTEIN 4A (DIM1)","Plasmodium yoelii",4,"ASP A  53;ASP A  95;ASN A 121;GLU A  61","None","1.29A","1rjdB-2av4A:undetectable","1rjdB-2av4A:20.30"],["1RJD_C_SAMC803_1","CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT","2av4","THIOREDOXIN-LIKE PROTEIN 4A (DIM1)","Plasmodium yoelii",4,"ASP A  53;ASP A  95;ASN A 121;GLU A  61","None","1.30A","1rjdC-2av4A:undetectable","1rjdC-2av4A:20.30"]]