SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2avt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 9 PHE A 175
LEU A 135
ILE A 231
VAL A 201
ILE A 167
 None
 1.40A 1gebA-2avtA:
undetectable		 1gebA-2avtA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 6 PHE A 215
PHE A 240
GLU A 210
LEU A 208
 None
 0.99A 1hk1A-2avtA:
undetectable		 1hk1A-2avtA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 10 LEU A 359
VAL A 264
ILE A 299
VAL A 346
ILE A 348
 None
 0.93A 1hsgA-2avtA:
undetectable		 1hsgA-2avtA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 9 LEU A 359
VAL A 264
ILE A 299
VAL A 346
ILE A 348
 None
 0.88A 1ohrB-2avtA:
undetectable		 1ohrB-2avtA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 LEU A 292
GLY A 322
ILE A 299
LEU A 338
THR A 268
 None
 1.10A 1p91B-2avtA:
undetectable		 1p91B-2avtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 LEU A 325
ILE A 299
PHE A 266
SER A 319
GLN A 320
 None
 1.37A 1xomB-2avtA:
undetectable		 1xomB-2avtA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 8 SER A 282
LEU A 292
LEU A 271
LEU A 338
 None
 1.01A 2bfpD-2avtA:
undetectable		 2bfpD-2avtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 8 TYR A 123
LEU A  76
ASN A  26
GLU A  78
 None
 0.98A 2bnnA-2avtA:
undetectable
2bnnB-2avtA:
undetectable		 2bnnA-2avtA:
21.22
2bnnB-2avtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 LEU A 359
VAL A 264
ILE A 299
VAL A 346
ILE A 348
 None
 0.97A 2pynB-2avtA:
undetectable		 2pynB-2avtA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 LEU A 359
VAL A 264
ILE A 299
VAL A 346
ILE A 348
 None
 0.89A 2qakB-2avtA:
undetectable		 2qakB-2avtA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 8 VAL A 354
THR A 373
PRO A 374
VAL A 375
 None
 1.00A 2v32C-2avtA:
undetectable
2v32D-2avtA:
undetectable		 2v32C-2avtA:
20.86
2v32D-2avtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		3 / 3 LEU A 371
MET A 185
MET A 275
 None
 1.00A 2vavF-2avtA:
undetectable		 2vavF-2avtA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 ILE A 146
PHE A 199
PHE A 226
VAL A 224
VAL A 222
 None
 1.12A 2ygpA-2avtA:
undetectable		 2ygpA-2avtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 PHE A  11
LEU A  77
PHE A  82
ILE A   2
ALA A  74
 None
 1.12A 3nxuB-2avtA:
undetectable		 3nxuB-2avtA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 11 ASP A 314
GLU A 293
HIS A 302
LEU A 315
ILE A 299
 None
 1.14A 3o94A-2avtA:
undetectable		 3o94A-2avtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 11 ASP A 314
GLU A 293
HIS A 302
LEU A 315
ILE A 299
 None
 1.14A 3o94B-2avtA:
undetectable		 3o94B-2avtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 10 ILE A  12
SER A 108
SER A 111
ILE A 113
ILE A  86
 None
 1.31A 3qgtA-2avtA:
undetectable		 3qgtA-2avtA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 7 VAL A 224
LEU A 137
LEU A 142
ILE A 167
 None
 0.99A 3u5kB-2avtA:
undetectable		 3u5kB-2avtA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 8 PHE A 266
SER A 328
GLU A 293
VAL A 290
 None
 0.69A 3ua5A-2avtA:
undetectable		 3ua5A-2avtA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 PHE A 350
LEU A 359
ILE A 299
SER A 337
VAL A 290
 None
 1.33A 3w1wA-2avtA:
undetectable		 3w1wA-2avtA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 PHE A  82
PHE A  11
ILE A   6
PHE A   4
LEU A 106
 None
 1.00A 4e1gA-2avtA:
undetectable		 4e1gA-2avtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 PHE A  82
PHE A  11
ILE A   6
PHE A   4
LEU A 106
 None
 1.03A 4e1gB-2avtA:
undetectable		 4e1gB-2avtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 ILE A   2
ILE A  94
LEU A  15
LEU A  45
ILE A  36
 None
 1.09A 4m2xE-2avtA:
undetectable		 4m2xE-2avtA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 10 LEU A  15
LEU A  45
ILE A  86
THR A  39
VAL A 104
 None
 1.41A 4mk4A-2avtA:
undetectable		 4mk4A-2avtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 8 PHE A 199
ILE A 167
PHE A 226
ILE A 146
 None
 0.98A 4qogA-2avtA:
undetectable
4qogB-2avtA:
undetectable		 4qogA-2avtA:
21.54
4qogB-2avtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 7 PHE A   4
ILE A  85
LEU A  77
PHE A  82
 None
 1.00A 4uymA-2avtA:
undetectable		 4uymA-2avtA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 7 PHE A   4
ILE A  85
LEU A  77
PHE A  82
 None
 0.97A 4uymB-2avtA:
undetectable		 4uymB-2avtA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 LEU A  45
LEU A  89
ILE A  94
LEU A 115
PHE A  82
 None
 1.13A 4y0qA-2avtA:
undetectable		 4y0qA-2avtA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 7 LEU A 162
THR A 180
PRO A 250
LEU A 371
 None
 0.42A 5fxtA-2avtA:
36.5		 5fxtA-2avtA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		4 / 8 THR A 180
PRO A 250
PRO A 356
LEU A 371
 None
 0.61A 5g48A-2avtA:
35.9		 5g48A-2avtA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 9 LEU A 162
THR A 180
PRO A 250
PRO A 356
LEU A 371
 None
 0.57A 5g48B-2avtA:
9.5		 5g48B-2avtA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		3 / 3 SER A 321
SER A 319
PHE A 260
 None
 0.92A 5mugA-2avtA:
undetectable		 5mugA-2avtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		3 / 3 ALA A 147
PHE A 151
GLN A 370
 None
 0.82A 6eceA-2avtA:
undetectable		 6eceA-2avtA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2avt DNA POLYMERASE III
BETA SUBUNIT
(Streptococcus
pyogenes) 		5 / 12 ILE A 167
VAL A 201
VAL A 165
PHE A 233
PHE A 211
 None
 1.30A 6j21A-2avtA:
undetectable		 6j21A-2avtA:
21.11