SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 9 ILE A 382
LEU A 376
VAL A 334
GLY A 301
LEU A 364
 None
 1.12A 1e7aB-2aw5A:
undetectable		 1e7aB-2aw5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 4 LEU A  44
PRO A  45
LEU A  28
ARG A  81
 None
 1.24A 1hrkB-2aw5A:
undetectable		 1hrkB-2aw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 172
PHE A  86
THR A 178
TYR A  87
 None
 1.35A 2axnA-2aw5A:
undetectable		 2axnA-2aw5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 PHE A 430
ALA A 284
ALA A 405
GLY A 450
GLY A 452
 None
 1.16A 2igtA-2aw5A:
2.1		 2igtA-2aw5A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 PHE A 430
ALA A 284
ALA A 405
GLY A 450
GLY A 452
 None
 1.14A 2igtB-2aw5A:
4.5		 2igtB-2aw5A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 4 LEU A  44
PRO A  45
LEU A  28
ARG A  81
 None
 1.27A 2pnjB-2aw5A:
undetectable		 2pnjB-2aw5A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 LEU A 441
PRO A 442
ARG A 427
 None
 0.50A 2qd4B-2aw5A:
3.6		 2qd4B-2aw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 7 GLY A 182
GLY A 172
GLN A  79
PHE A  86
 None
 0.92A 2qwxA-2aw5A:
3.7
2qwxB-2aw5A:
3.9		 2qwxA-2aw5A:
17.27
2qwxB-2aw5A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 8 ALA A 327
LEU A 317
LEU A 292
ILE A 297
VAL A 278
 None
 1.41A 2uxpA-2aw5A:
0.3		 2uxpA-2aw5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 ALA A 467
ALA A 514
SER A 510
ALA A 462
 None
 0.91A 2vh3B-2aw5A:
undetectable		 2vh3B-2aw5A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 10 GLU A  95
GLY A 433
ALA A 405
LEU A 499
ARG A 498
 None
 1.35A 3a3yA-2aw5A:
undetectable		 3a3yA-2aw5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 11 VAL A 466
GLY A 464
ILE A 513
LYS A 512
SER A 510
 None
 1.09A 3bjwB-2aw5A:
undetectable		 3bjwB-2aw5A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 VAL A 466
GLY A 464
ILE A 513
LYS A 512
SER A 510
 None
 1.13A 3bjwF-2aw5A:
undetectable		 3bjwF-2aw5A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 11 VAL A 466
GLY A 464
ILE A 513
LYS A 512
SER A 510
 None
 1.07A 3bjwH-2aw5A:
undetectable		 3bjwH-2aw5A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 LEU A 339
GLY A 301
ALA A 302
ILE A 297
ILE A 340
 None
 0.89A 3cywA-2aw5A:
undetectable		 3cywA-2aw5A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 GLY A 280
ALA A 279
GLY A 272
VAL A 509
ILE A 485
 None
 0.91A 3cyxB-2aw5A:
undetectable		 3cyxB-2aw5A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 9 GLU A  63
VAL A  59
ILE A 100
LEU A  75
PHE A  97
 None
 1.30A 3fl9H-2aw5A:
undetectable		 3fl9H-2aw5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 PHE A 458
ILE A 485
VAL A 509
GLY A 460
 None
 0.71A 3hjoB-2aw5A:
undetectable		 3hjoB-2aw5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 7 PHE A 478
VAL A 461
VAL A 465
LEU A 470
 None
 0.86A 3hs6B-2aw5A:
undetectable		 3hs6B-2aw5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 GLY A 280
GLY A 450
ALA A 431
PHE A 430
ALA A 405
 None
 1.05A 3sudA-2aw5A:
undetectable		 3sudA-2aw5A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 GLY A 182
GLY A 464
ALA A 462
SER A 275
ASP A 268
 None
 0.98A 3sudD-2aw5A:
undetectable		 3sudD-2aw5A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 6 ASP A 152
GLY A 196
VAL A 195
ASP A 194
 None
 1.20A 3vqrA-2aw5A:
undetectable		 3vqrA-2aw5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 ASP A 152
GLY A 196
VAL A 195
ASP A 194
 None
 1.19A 3vqrB-2aw5A:
undetectable		 3vqrB-2aw5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 6 PHE A 299
ALA A 306
ALA A 274
THR A 273
 None
 1.08A 4dtzB-2aw5A:
undetectable		 4dtzB-2aw5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 ARG A 155
VAL A 379
LEU A 406
SER A 407
 None
 1.31A 4e1gA-2aw5A:
undetectable		 4e1gA-2aw5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 8 ALA A 279
VAL A 457
GLY A 452
VAL A 509
ILE A 485
 None
 1.25A 4ll3A-2aw5A:
undetectable		 4ll3A-2aw5A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 9 ALA A 279
VAL A 457
GLY A 452
VAL A 509
ILE A 485
 None
 1.24A 4ll3B-2aw5A:
undetectable		 4ll3B-2aw5A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 TYR A 177
PHE A 458
PHE A 266
ILE A 156
 None
 0.98A 4qoiA-2aw5A:
2.8
4qoiB-2aw5A:
2.8		 4qoiA-2aw5A:
17.27
4qoiB-2aw5A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 ALA A 413
SER A 407
GLY A 378
GLN A 300
PHE A 386
 None
 1.32A 4r29A-2aw5A:
undetectable		 4r29A-2aw5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 ALA A 413
SER A 407
GLY A 433
ILE A 429
ALA A 428
 None
 0.99A 4r29D-2aw5A:
undetectable		 4r29D-2aw5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 LEU A 312
ALA A 279
VAL A 461
ILE A 513
 None
 0.93A 4xe3A-2aw5A:
undetectable		 4xe3A-2aw5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 LEU A 312
ALA A 279
VAL A 461
ILE A 513
 None
 0.97A 4xe3B-2aw5A:
undetectable		 4xe3B-2aw5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 LYS A 173
ILE A 169
ILE A 156
 None
 0.60A 4y0qA-2aw5A:
undetectable		 4y0qA-2aw5A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 GLU A  83
HIS A  23
ASP A  80
 None
 0.85A 5c0oG-2aw5A:
4.1		 5c0oG-2aw5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 VAL A 276
ALA A 274
ARG A 155
ILE A 270
ASN A 454
 None
 1.44A 5hgcA-2aw5A:
undetectable		 5hgcA-2aw5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 7 GLY A 450
LEU A 282
GLY A 433
LEU A 406
ILE A 313
 None
 1.00A 5vkqA-2aw5A:
2.1
5vkqB-2aw5A:
2.2		 5vkqA-2aw5A:
15.26
5vkqB-2aw5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 8 GLY A 450
LEU A 282
GLY A 433
LEU A 406
ILE A 313
 None
 0.99A 5vkqB-2aw5A:
2.2
5vkqC-2aw5A:
2.1		 5vkqB-2aw5A:
15.26
5vkqC-2aw5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 9 GLY A 450
LEU A 282
GLY A 433
LEU A 406
ILE A 313
 None
 0.97A 5vkqC-2aw5A:
undetectable
5vkqD-2aw5A:
1.7		 5vkqC-2aw5A:
15.26
5vkqD-2aw5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 LEU A 256
SER A 275
THR A 481
VAL A 457
LEU A 307
 None
 1.28A 6djzB-2aw5A:
undetectable		 6djzB-2aw5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 PHE A 244
VAL A 465
MET A 229
VAL A 150
 None
 0.86A 6ekzA-2aw5A:
undetectable		 6ekzA-2aw5A:
10.02