SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2awa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A  77
VAL A  34
ILE A  36
LEU A  94
VAL A  86
 None
 1.17A 1cqpA-2awaA:
undetectable
1cqpB-2awaA:
undetectable		 1cqpA-2awaA:
19.55
1cqpB-2awaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 1dz4A-2awaA:
undetectable		 1dz4A-2awaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 1dz4B-2awaA:
undetectable		 1dz4B-2awaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A 280
GLU A 276
ALA A 278
LEU A 281
 None
 1.04A 1eta1-2awaA:
undetectable		 1eta1-2awaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A 280
GLU A 276
ALA A 278
LEU A 281
 None
 1.05A 1eta2-2awaA:
undetectable		 1eta2-2awaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 280
GLU A 276
ALA A 278
LEU A 281
 None
 1.03A 1etb1-2awaA:
undetectable		 1etb1-2awaA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 9 PHE A  11
LEU A  77
VAL A  34
VAL A  38
ILE A  43
 None
 1.11A 1gebA-2awaA:
undetectable		 1gebA-2awaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A 215
PHE A 240
GLU A 210
LEU A 208
 None
 0.92A 1hk1A-2awaA:
undetectable		 1hk1A-2awaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 1iwiA-2awaA:
undetectable		 1iwiA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		3 / 3 ILE A 327
LEU A 292
VAL A 299
 None
 0.48A 1mz9B-2awaA:
undetectable		 1mz9B-2awaA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.97A 1t85A-2awaA:
0.0		 1t85A-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 1t87A-2awaA:
undetectable		 1t87A-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
ILE A  43
 None
 1.16A 1t87B-2awaA:
undetectable		 1t87B-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 1t88B-2awaA:
undetectable		 1t88B-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 359
ILE A 294
LEU A 292
THR A 317
PHE A 266
 None
 1.36A 1tw4A-2awaA:
1.4		 1tw4A-2awaA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A  21
ILE A  22
ILE A  54
ALA A  14
LEU A  12
 None
 0.91A 1uduB-2awaA:
undetectable		 1uduB-2awaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.92A 1yrcA-2awaA:
undetectable		 1yrcA-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.91A 1yrdA-2awaA:
undetectable		 1yrdA-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 9 PHE A  11
LEU A  77
VAL A  34
VAL A  38
ILE A  43
 None
 1.17A 2a1oB-2awaA:
undetectable		 2a1oB-2awaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.97A 2cppA-2awaA:
undetectable		 2cppA-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.92A 2feuA-2awaA:
undetectable		 2feuA-2awaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 2feuB-2awaA:
0.0		 2feuB-2awaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		3 / 3 GLN A 370
LYS A 188
VAL A 178
 None
 0.83A 2jfaB-2awaA:
undetectable		 2jfaB-2awaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 2m56A-2awaA:
undetectable		 2m56A-2awaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A 325
PHE A 260
ILE A 327
PHE A 357
 None
 0.97A 2opxA-2awaA:
undetectable		 2opxA-2awaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.88A 2qblA-2awaA:
undetectable		 2qblA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 280
GLU A 276
ALA A 278
LEU A 281
 None
 0.99A 2roxB-2awaA:
undetectable		 2roxB-2awaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 ILE A 231
LEU A 175
LEU A 137
ILE A 224
PHE A 226
 None
None
GOL  A 379 ( 4.5A)
None
None
 1.07A 2w9sA-2awaA:
undetectable		 2w9sA-2awaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 ILE A 231
LEU A 175
LEU A 137
ILE A 224
PHE A 226
 None
None
GOL  A 379 ( 4.5A)
None
None
 1.07A 2w9sB-2awaA:
undetectable		 2w9sB-2awaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 10 ILE A 231
LEU A 175
LEU A 137
ILE A 224
PHE A 226
 None
None
GOL  A 379 ( 4.5A)
None
None
 1.08A 2w9sF-2awaA:
undetectable		 2w9sF-2awaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A   6
ILE A  58
ILE A 104
PHE A  11
VAL A  34
 None
 1.06A 2ygoA-2awaA:
undetectable		 2ygoA-2awaA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.96A 2zawA-2awaA:
undetectable		 2zawA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 2zaxA-2awaA:
undetectable		 2zaxA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.98A 2zuhA-2awaA:
undetectable		 2zuhA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 2zuiA-2awaA:
undetectable		 2zuiA-2awaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 2zwtA-2awaA:
undetectable		 2zwtA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 2zwuA-2awaA:
undetectable		 2zwuA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3fwfA-2awaA:
0.0		 3fwfA-2awaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3fwfB-2awaA:
undetectable		 3fwfB-2awaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.92A 3fwgA-2awaA:
undetectable		 3fwgA-2awaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3fwgB-2awaA:
undetectable		 3fwgB-2awaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 3fwiA-2awaA:
undetectable		 3fwiA-2awaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3fwjA-2awaA:
undetectable		 3fwjA-2awaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3l63A-2awaA:
undetectable		 3l63A-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 SER A  23
TYR A 123
ASN A  26
LEU A  31
 None
 1.41A 3lslA-2awaA:
undetectable
3lslD-2awaA:
undetectable		 3lslA-2awaA:
20.90
3lslD-2awaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  66
ALA A  65
GLY A  42
ILE A  69
ILE A  43
 None
 1.00A 3n3iA-2awaA:
undetectable		 3n3iA-2awaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  43
ALA A  14
THR A  18
VAL A  34
LEU A  76
 None
 1.22A 3s79A-2awaA:
undetectable		 3s79A-2awaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A 176
VAL A 178
HIS A 166
 None
 0.83A 3tj7A-2awaA:
undetectable		 3tj7A-2awaA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 192
LEU A 141
ILE A 136
ILE A 224
THR A 177
 GOL  A 379 ( 4.0A)
GOL  A 379 (-4.2A)
None
None
None
 1.03A 3tqbA-2awaA:
undetectable		 3tqbA-2awaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 ILE A  43
PHE A   4
SER A  87
THR A  18
 None
 0.73A 3ua5A-2awaA:
undetectable		 3ua5A-2awaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3wrhA-2awaA:
undetectable		 3wrhA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.96A 3wrhE-2awaA:
undetectable		 3wrhE-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 3wrjA-2awaA:
undetectable		 3wrjA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 3wrjE-2awaA:
undetectable		 3wrjE-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 3wrlA-2awaA:
undetectable		 3wrlA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 3wrlE-2awaA:
undetectable		 3wrlE-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 3wrmA-2awaA:
undetectable		 3wrmA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.95A 3wrmF-2awaA:
undetectable		 3wrmF-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 VAL A  86
LEU A 106
LEU A  94
ILE A  36
 None
 0.92A 4a9jC-2awaA:
undetectable		 4a9jC-2awaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A  82
PHE A  11
ILE A   6
PHE A   4
LEU A 106
 None
 1.00A 4e1gA-2awaA:
undetectable		 4e1gA-2awaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A  82
PHE A  11
ILE A   6
PHE A   4
LEU A 106
 None
 1.04A 4e1gB-2awaA:
undetectable		 4e1gB-2awaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.96A 4ek1A-2awaA:
undetectable		 4ek1A-2awaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.97A 4g3rA-2awaA:
undetectable		 4g3rA-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.96A 4g3rB-2awaA:
undetectable		 4g3rB-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.97A 4kkyX-2awaA:
undetectable		 4kkyX-2awaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.92A 4l49A-2awaA:
undetectable		 4l49A-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A  96
LEU A  45
VAL A  34
VAL A  86
 None
 1.22A 4l49A-2awaA:
undetectable		 4l49A-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.93A 4l4aA-2awaA:
undetectable		 4l4aA-2awaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.99A 4l4cA-2awaA:
undetectable		 4l4cA-2awaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.94A 4l4dA-2awaA:
undetectable		 4l4dA-2awaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 1.00A 4l4gA-2awaA:
undetectable		 4l4gA-2awaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 SER A  74
GLU A  98
VAL A  34
THR A  33
 None
 1.38A 4lnxA-2awaA:
undetectable		 4lnxA-2awaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 ILE A  36
ILE A   6
PHE A  82
LEU A 106
 None
 0.94A 4m51A-2awaA:
undetectable		 4m51A-2awaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 169
LEU A 141
LEU A 142
ILE A 145
LEU A 192
 None
GOL  A 379 (-4.2A)
None
None
GOL  A 379 ( 4.0A)
 0.99A 4zowA-2awaA:
undetectable		 4zowA-2awaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 ILE A  43
PHE A  11
VAL A  38
ILE A   2
 None
 0.95A 4zzbC-2awaA:
undetectable
4zzbD-2awaA:
undetectable		 4zzbC-2awaA:
21.38
4zzbD-2awaA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A 162
THR A 180
PRO A 250
LEU A 371
 None
 0.53A 5fxtA-2awaA:
36.7		 5fxtA-2awaA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A 185
PRO A 250
PRO A 356
LEU A 371
 None
 0.68A 5g48A-2awaA:
36.1		 5g48A-2awaA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 THR A 180
LEU A 185
PRO A 250
LEU A 371
 None
 0.75A 5g48A-2awaA:
36.1		 5g48A-2awaA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		6 / 9 LEU A 162
THR A 180
LEU A 185
PRO A 250
PRO A 356
LEU A 371
 None
 0.76A 5g48B-2awaA:
36.3		 5g48B-2awaA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  43
ALA A  14
THR A  18
VAL A  34
LEU A  76
 None
 1.24A 5jkvA-2awaA:
undetectable		 5jkvA-2awaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 9 ILE A 146
PHE A 211
VAL A 165
THR A 177
 None
 0.94A 5lg3I-2awaA:
undetectable		 5lg3I-2awaA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 ILE A 335
ILE A 264
LEU A 292
PHE A 329
 None
 1.04A 5vkqB-2awaA:
undetectable
5vkqC-2awaA:
undetectable		 5vkqB-2awaA:
13.10
5vkqC-2awaA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 ILE A 335
ILE A 264
LEU A 292
PHE A 329
 None
 1.03A 5vkqC-2awaA:
undetectable
5vkqD-2awaA:
undetectable		 5vkqC-2awaA:
13.10
5vkqD-2awaA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2awa DNA POLYMERASE III,
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.99A 5wk9A-2awaA:
0.0		 5wk9A-2awaA:
22.66