SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2awc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
HIS A  59
TYR A 126
PHE A  67
 FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
None
None
 1.25A 1eqbA-2awcA:
undetectable
1eqbB-2awcA:
undetectable		 1eqbA-2awcA:
15.44
1eqbB-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 TYR A 126
PHE A  67
HIS A 118
HIS A  59
 None
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 1.25A 1eqbA-2awcA:
undetectable
1eqbB-2awcA:
undetectable		 1eqbA-2awcA:
15.44
1eqbB-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
HIS A  59
TYR A 126
PHE A  67
 FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
None
None
 1.24A 1eqbC-2awcA:
undetectable
1eqbD-2awcA:
undetectable		 1eqbC-2awcA:
15.44
1eqbD-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 TYR A 126
PHE A  67
HIS A 118
HIS A  59
 None
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 1.24A 1eqbC-2awcA:
undetectable
1eqbD-2awcA:
undetectable		 1eqbC-2awcA:
15.44
1eqbD-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.26A 1v7zA-2awcA:
undetectable		 1v7zA-2awcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.27A 1v7zB-2awcA:
undetectable		 1v7zB-2awcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.31A 1v7zC-2awcA:
undetectable		 1v7zC-2awcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 6 ILE A  19
HIS A  78
HIS A  82
HIS A 118
 None
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 0.87A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 6 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.82A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 6 ILE A  19
HIS A 118
HIS A  78
HIS A  82
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
 0.82A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
ASP A 123
ILE A  19
HIS A  82
 FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.3A)
 0.87A 2xadC-2awcA:
undetectable		 2xadC-2awcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
ASP A 123
ILE A  19
HIS A  82
 FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.3A)
 0.90A 2xadD-2awcA:
undetectable		 2xadD-2awcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jA-2awcA:
undetectable		 3a6jA-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
ASP A 123
HIS A  78
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-2.5A)
FEO  A 137 (-3.5A)
None
FEO  A 137 (-3.4A)
 1.40A 3a6jC-2awcA:
undetectable		 3a6jC-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jC-2awcA:
undetectable		 3a6jC-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jE-2awcA:
undetectable		 3a6jE-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
ASP A 123
HIS A  78
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-2.5A)
FEO  A 137 (-3.5A)
None
FEO  A 137 (-3.4A)
 1.41A 3a6jF-2awcA:
undetectable		 3a6jF-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jF-2awcA:
undetectable		 3a6jF-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.98A 3ljgA-2awcA:
undetectable		 3ljgA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		3 / 3 LYS A 121
GLU A 122
TRP A 114
 None
 1.32A 3v4tH-2awcA:
undetectable		 3v4tH-2awcA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 GLN A  22
HIS A  59
HIS A  82
LEU A  66
 None
FEO  A 137 (-3.4A)
FEO  A 137 (-3.3A)
None
 1.05A 3w6hA-2awcA:
undetectable		 3w6hA-2awcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.83A 4p6sA-2awcA:
undetectable		 4p6sA-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.83A 4p6sB-2awcA:
undetectable		 4p6sB-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 VAL A  86
PHE A  60
HIS A  59
GLU A  58
 None
FEO  A 137 ( 4.8A)
FEO  A 137 (-3.4A)
None
 1.06A 5ad9A-2awcA:
2.4
5ad9B-2awcA:
2.2		 5ad9A-2awcA:
16.75
5ad9B-2awcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.85A 5i3aA-2awcA:
undetectable		 5i3aA-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.84A 5i3aB-2awcA:
undetectable		 5i3aB-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.92A 5i3bA-2awcA:
undetectable		 5i3bA-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A  78
HIS A  82
HIS A 118
 None
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 0.91A 5n5kA-2awcA:
undetectable		 5n5kA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.83A 5n5kA-2awcA:
undetectable		 5n5kA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A 118
HIS A  78
HIS A  82
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
 0.84A 5n5kA-2awcA:
undetectable		 5n5kA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 11 HIS A  59
ILE A  19
HIS A  23
HIS A 118
HIS A  82
 FEO  A 137 (-3.4A)
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 1.39A 5z0gA-2awcA:
undetectable
5z0gB-2awcA:
undetectable		 5z0gA-2awcA:
20.00
5z0gB-2awcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 11 HIS A  59
ILE A  19
HIS A  23
HIS A 118
HIS A  82
 FEO  A 137 (-3.4A)
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 1.39A 5z0iA-2awcA:
undetectable
5z0iB-2awcA:
undetectable		 5z0iA-2awcA:
20.00
5z0iB-2awcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 12 PHE A  85
ASN A  15
LEU A  16
PHE A  60
TYR A  72
 None
None
None
FEO  A 137 ( 4.8A)
None
 1.25A 6r2eA-2awcA:
undetectable		 6r2eA-2awcA:
15.71