SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2awg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.94A 1dz4A-2awgA:
undetectable		 1dz4A-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.98A 1dz4B-2awgA:
undetectable		 1dz4B-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.88A 1iwiA-2awgA:
undetectable		 1iwiA-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 143
VAL A 152
ILE A 153
TYR A 179
ILE A 188
 None
 0.65A 1pbkA-2awgA:
16.4		 1pbkA-2awgA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.95A 1t85A-2awgA:
undetectable		 1t85A-2awgA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.93A 1t87A-2awgA:
undetectable		 1t87A-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.94A 1yrdA-2awgA:
undetectable		 1yrdA-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.93A 2qblA-2awgA:
undetectable		 2qblA-2awgA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 143
VAL A 152
ILE A 153
TYR A 179
ILE A 188
 None
 0.59A 3kz7A-2awgA:
16.8		 3kz7A-2awgA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 8 VAL A 152
ILE A 153
TYR A 179
ILE A 188
 None
 0.31A 3uqbA-2awgA:
18.8		 3uqbA-2awgA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.98A 4g3rA-2awgA:
undetectable		 4g3rA-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 0.94A 4g3rB-2awgA:
undetectable		 4g3rB-2awgA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 200
VAL A 198
VAL A 152
ASP A 157
 None
 1.00A 4l4cA-2awgA:
undetectable		 4l4cA-2awgA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 143
VAL A 152
ILE A 153
TYR A 179
ILE A 188
 None
 0.75A 5d75A-2awgA:
17.1		 5d75A-2awgA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 127
THR A 129
ILE A 188
LEU A 131
 None
 1.04A 5fxtA-2awgA:
undetectable		 5fxtA-2awgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2awg 38 KDA FK-506
BINDING PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 143
VAL A 152
ILE A 153
TYR A 179
ILE A 188
 None
 0.55A 5gpgA-2awgA:
17.5		 5gpgA-2awgA:
29.46