SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ax4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		4 / 5 ARG A 176
LYS A 175
ALA A 177
GLY A 180
 None
 1.17A 1e7cA-2ax4A:
undetectable		 1e7cA-2ax4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		5 / 12 ARG A 176
ILE A 182
PHE A 185
ILE A 132
TYR A 174
 None
 1.43A 1ot7A-2ax4A:
0.0		 1ot7A-2ax4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		4 / 8 SER A 133
PHE A 131
VAL A 116
LEU A  95
 None
 1.04A 3jq7C-2ax4A:
5.2		 3jq7C-2ax4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		5 / 10 VAL A 226
ILE A  81
ILE A 128
VAL A  55
VAL A 126
 None
 1.04A 3me6A-2ax4A:
undetectable		 3me6A-2ax4A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		3 / 3 GLY A  62
GLY A  64
THR A  66
 ADP  A 800 (-3.3A)
ADP  A 800 (-3.3A)
ADP  A 800 (-3.6A)
 0.43A 3si7B-2ax4A:
3.0		 3si7B-2ax4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		4 / 6 GLU A 147
GLY A  41
ARG A  51
GLY A 124
 None
 0.59A 5cdnC-2ax4A:
undetectable
5cdnD-2ax4A:
undetectable		 5cdnC-2ax4A:
15.18
5cdnD-2ax4A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens) 		4 / 6 GLU A 147
GLY A  41
ARG A  51
GLY A 124
 None
 0.60A 5cdnT-2ax4A:
undetectable
5cdnU-2ax4A:
undetectable		 5cdnT-2ax4A:
15.18
5cdnU-2ax4A:
24.77