SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2axc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 8 ALA A 126
GLY A 259
ALA A 254
THR A 181
 None
 0.73A 1gtnI-2axcA:
undetectable
1gtnJ-2axcA:
undetectable		 1gtnI-2axcA:
14.02
1gtnJ-2axcA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 6 LEU A 131
ILE A 191
PRO A  88
VAL A 162
 None
 1.15A 2ygoA-2axcA:
undetectable		 2ygoA-2axcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 8 SER A 108
GLY A 248
GLU A 245
ILE A 129
 None
 0.86A 3aodA-2axcA:
undetectable		 3aodA-2axcA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2axc COLICIN E7
(Escherichia
coli) 		5 / 12 SER A 153
PHE A 219
ILE A 100
ALA A  91
GLY A 261
 GOL  A 401 (-2.8A)
None
GOL  A 401 (-4.0A)
None
None
 1.07A 3nxuA-2axcA:
undetectable		 3nxuA-2axcA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2axc COLICIN E7
(Escherichia
coli) 		5 / 12 LEU A 239
THR A 283
ILE A 150
VAL A 183
ASP A 246
 None
 1.24A 3vw1D-2axcA:
undetectable		 3vw1D-2axcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 5 ILE A 267
VAL A 278
PHE A  87
HIS A 216
 None
 1.03A 4rzvA-2axcA:
undetectable		 4rzvA-2axcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2axc COLICIN E7
(Escherichia
coli) 		5 / 8 ALA A 110
ALA A 112
ILE A 111
PHE A  85
LEU A 154
 None
 1.35A 4v1fA-2axcA:
undetectable
4v1fB-2axcA:
undetectable		 4v1fA-2axcA:
17.79
4v1fB-2axcA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 7 ARG A 179
ALA A 254
ILE A 129
LEU A 118
 None
 0.87A 5te8A-2axcA:
undetectable		 5te8A-2axcA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 8 ARG A 179
ALA A 254
ILE A 129
LEU A 118
 None
 0.83A 5te8B-2axcA:
undetectable		 5te8B-2axcA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2axc COLICIN E7
(Escherichia
coli) 		5 / 12 VAL A 180
PHE A 219
ILE A 267
VAL A 227
SER A 153
 None
None
None
None
GOL  A 401 (-2.8A)
 1.32A 6ap6A-2axcA:
undetectable		 6ap6A-2axcA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2axc COLICIN E7
(Escherichia
coli) 		5 / 12 VAL A 180
PHE A 219
ILE A 267
VAL A 227
SER A 153
 None
None
None
None
GOL  A 401 (-2.8A)
 1.31A 6ap6B-2axcA:
undetectable		 6ap6B-2axcA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 8 ILE A 191
GLN A 189
VAL A 183
ALA A 254
 None
 0.90A 6cduD-2axcA:
undetectable
6cduE-2axcA:
undetectable		 6cduD-2axcA:
20.53
6cduE-2axcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2axc COLICIN E7
(Escherichia
coli) 		4 / 7 ALA A 254
ILE A 191
GLN A 189
VAL A 183
 None
 0.86A 6cduF-2axcA:
undetectable
6cduJ-2axcA:
undetectable		 6cduF-2axcA:
20.53
6cduJ-2axcA:
20.53